CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-024601
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 NAD(P)H-hydrate epimerase 
Protein Synonyms/Alias
 Apolipoprotein A-I-binding protein; AI-BP; NAD(P)HX epimerase 
Gene Name
 Apoa1bp 
Gene Synonyms/Alias
 Aibp 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
142YYPKRPNKPLFTGLVacetylation[1]
263FVPPALEKKYQLNLPacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S- specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX (By similarity). 
Sequence Annotation
 DOMAIN 59 269 YjeF N-terminal.
 REGION 113 117 NAD(P)HX (By similarity).
 REGION 183 189 NAD(P)HX (By similarity).
 METAL 114 114 Potassium (By similarity).
 METAL 179 179 Potassium (By similarity).
 METAL 215 215 Potassium (By similarity).
 BINDING 212 212 NAD(P)HX (By similarity).  
Keyword
 Complete proteome; Isomerase; Metal-binding; Mitochondrion; NAD; NADP; Nucleotide-binding; Phosphoprotein; Potassium; Reference proteome; Secreted; Transit peptide. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 282 AA 
Protein Sequence
MSGLRTLLGL GLLVAGSRLP RIASRQSVCR AGPIWWGTQH RSSETMASAA VKYLSQEEAQ 60
AVDEELFNEY QFSVDQLMEL AGLSCATAIA KAYPPTSMSK SPPTVLVICG PGNNGGDGLV 120
CARHLKLFGY QPTIYYPKRP NKPLFTGLVT QCQKMDIPFL GEMPPEPMMV DELYELVVDA 180
IFGFSFKGDV REPFHSILSV LSGLTVPIAS IDIPSGWDVE KGNPSGIQPD LLISLTAPKK 240
SATQFTGRYH YLGGRFVPPA LEKKYQLNLP AYPDTECVYR LQ 282 
Gene Ontology
 GO:0044297; C:cell body; IEA:Compara.
 GO:0005615; C:extracellular space; IEA:Compara.
 GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0052856; F:NADHX epimerase activity; IEA:HAMAP.
 GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
 GO:0051289; P:protein homotetramerization; IEA:Compara. 
Interpro
 IPR026600; NnrE/AIBP.
 IPR004443; YjeF_N_dom. 
Pfam
 PF03853; YjeF_N 
SMART
  
PROSITE
 PS51385; YJEF_N 
PRINTS