UniProt Accession

 CD79B_HUMAN; P40259; Q53FS2; Q9BU06 

Genbank Protein ID

 M80461; M89957; S52229; L27587; S79249; X83539; AK222954; AK223210; BC002975; BC032651 

Genbank Nucleotide ID

 AAA58387.1; AAA64459.1; AAB24822.2; AAA72424.1; AAC60654.1; CAA58522.1; BAD96674.1; BAD96930.1; AAH02975.2; AAH32651.1 

Protein Name

 B-cell antigen receptor complex-associated protein beta chain 

Protein Synonyms/Alias

 B-cell-specific glycoprotein B29; Ig-beta; Immunoglobulin-associated B29 protein; CD79b 

Gene Name

 CD79B 

Gene Synonyms/Alias

 B29; IGB 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
152	FSTLAQLKQRNTLKD	ubiquitination	[1]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation. 

Sequence Annotation

 DOMAIN 38 138 Ig-like V-type.
 DOMAIN 185 213 ITAM.
 MOD_RES 196 196 Phosphotyrosine; by SRC-type Tyr-kinases
 MOD_RES 207 207 Phosphotyrosine; by SRC-type Tyr-kinases
 CARBOHYD 73 73 N-linked (GlcNAc...) (Potential).
 CARBOHYD 101 101 N-linked (GlcNAc...) (Potential).
 CARBOHYD 127 127 N-linked (GlcNAc...) (Potential).
 CARBOHYD 128 128 N-linked (GlcNAc...) (Potential).
 DISULFID 43 126
 DISULFID 65 122
 DISULFID 136 136 Interchain (with C-119 in alpha chain).  

Keyword

 3D-structure; Adaptive immunity; Alternative splicing; Cell membrane; Complete proteome; Direct protein sequencing; Disease mutation; Disulfide bond; Glycoprotein; Immunity; Immunoglobulin domain; Membrane; Phosphoprotein; Reference proteome; Signal; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 229 AA 

Protein Sequence

Gene Ontology

 GO:0019815; C:B cell receptor complex; IEA:Compara.
 GO:0009897; C:external side of plasma membrane; IEA:Compara.
 GO:0005794; C:Golgi apparatus; IDA:HPA.
 GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
 GO:0050853; P:B cell receptor signaling pathway; IEA:Compara.
 GO:0006955; P:immune response; TAS:ProtInc.
 GO:0007165; P:signal transduction; TAS:ProtInc. 

Interpro

 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR003599; Ig_sub.
 IPR013106; Ig_V-set.
 IPR003110; Phos_immunorcpt_sig_ITAM. 

Pfam

 PF02189; ITAM
 PF07686; V-set 

SMART

 SM00409; IG
 SM00077; ITAM 

PROSITE

 PS50835; IG_LIKE
 PS51055; ITAM_1 

PRINTS