CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-011976
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Striatin-3 
Protein Synonyms/Alias
 Cell cycle autoantigen SG2NA; S/G2 antigen 
Gene Name
 STRN3 
Gene Synonyms/Alias
 GS2NA; SG2NA 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
173QNSQLTWKQGRQLLRubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
 Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein. 
Sequence Annotation
 REPEAT 478 517 WD 1.
 REPEAT 531 570 WD 2.
 REPEAT 584 623 WD 3.
 REPEAT 679 718 WD 4.
 REPEAT 721 760 WD 5.
 REPEAT 767 796 WD 6.
 REGION 71 79 Caveolin-binding (Potential).
 REGION 166 183 Calmodulin-binding (Potential).
 MOD_RES 229 229 Phosphoserine.
 MOD_RES 257 257 Phosphoserine.  
Keyword
 Alternative splicing; Calmodulin-binding; Coiled coil; Complete proteome; Cytoplasm; Membrane; Phosphoprotein; Polymorphism; Reference proteome; Repeat; WD repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 797 AA 
Protein Sequence
MDELAGGGGG GPGMAAPPRQ QQGPGGNLGL SPGGNGAAGG GGPPASEGAG PAAGPELSRP 60
QQYTIPGILH YIQHEWARFE MERAHWEVER AELQARIAFL QGERKGQENL KKDLVRRIKM 120
LEYALKQERA KYHKLKYGTE LNQGDLKMPT FESEETKDTE APTAPQNSQL TWKQGRQLLR 180
QYLQEVGYTD TILDVRSQRV RSLLGLSNSE PNGSVETKNL EQILNGGESP KQKGQEIKRS 240
SGDVLETFNF LENADDSDED EENDMIEGIP EGKDKHRMNK HKIGNEGLAA DLTDDPDTEE 300
ALKEFDFLVT AEDGEGAGEA RSSGDGTEWA EPITFPSGGG KSFIMGSDDV LLSVLGLGDL 360
ADLTVTNDAD YSYDLPANKD AFRKTWNPKY TLRSHFDGVR ALAFHPVEPV LVTASEDHTL 420
KLWNLQKTVP AKKSASLDVE PIYTFRAHIG PVLSLAISSN GEQCFSGGID ATIQWWNMPS 480
PSVDPYDTYE PNVLAGTLVG HTDAVWGLAY SGIKNQLLSC SADGTVRLWN PQEKLPCICT 540
YNGDKKHGIP TSVDFIGCDP AHMVTSFNTG SAVIYDLETS QSLVILSSQV DSGLQSNNHI 600
NRVVSHPTLP VTITAHEDRH IKFFDNKTGK MIHSMVAHLD AVTSLAVDPN GIYLMSGSHD 660
CSIRLWNLDS KTCVQEITAH RKKLDESIYD VAFHSSKAYI ASAGADALAK VFV 713 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:UniProtKB.
 GO:0030425; C:dendrite; ISS:UniProtKB.
 GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
 GO:0043025; C:neuronal cell body; ISS:UniProtKB.
 GO:0005654; C:nucleoplasm; IDA:UniProtKB.
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0005886; C:plasma membrane; IDA:UniProtKB.
 GO:0043234; C:protein complex; ISS:UniProtKB.
 GO:0005516; F:calmodulin binding; NAS:UniProtKB.
 GO:0032403; F:protein complex binding; IDA:UniProtKB.
 GO:0051721; F:protein phosphatase 2A binding; IDA:UniProtKB.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IDA:UniProtKB.
 GO:0033147; P:negative regulation of intracellular estrogen receptor signaling pathway; ISS:UniProtKB.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; IEA:Compara.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.
 GO:0032355; P:response to estradiol stimulus; ISS:UniProtKB. 
Interpro
 IPR020472; G-protein_beta_WD-40_rep.
 IPR013258; Striatin_N.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR019775; WD40_repeat_CS.
 IPR017986; WD40_repeat_dom. 
Pfam
 PF08232; Striatin
 PF00400; WD40 
SMART
 SM00320; WD40 
PROSITE
 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 
PRINTS
 PR00320; GPROTEINBRPT.