UniProt Accession

 TRIM5_HUMAN; Q9C035; A6NGQ1; A8WFA8; D3DQS8; D3DQS9; G3GJY1; Q2MLV4; Q2MLV8; Q2MLV9; Q2MLW1; Q2MLW3; Q2MLW4; Q2MLW6; Q2MLW7; Q2MLX1; Q2MLX2; Q2MLX3; Q2MLX5; Q2MLY3; Q2MLY4; Q2V6Q6; Q6GX26; Q8WU46; Q96SR5; Q9C031; Q9C032; Q9C033; Q9C034 

Genbank Protein ID

 AF220025; AF220026; AF220027; AF220028; AF220029; AY625000; DQ301444; DQ301445; DQ301446; DQ301447; DQ301448; DQ301449; DQ301450; DQ301451; DQ301452; DQ301453; DQ301454; DQ301455; DQ301456; DQ301457; DQ301458; DQ301459; DQ301460; DQ301461; DQ301462; DQ301463; DQ301464; DQ301465; DQ301466; DQ301467; DQ301468; DQ301469; DQ301470; DQ301471; DQ301472; DQ301473; DQ301474; DQ301475; DQ301476; DQ301477; DQ301478; DQ301479; DQ301480; DQ288685; JF928461; JF928462; AK027593; AC015691; CH471064; CH471064; CH471064; CH471064; EU260465; CH471064; CH471064; BC021258 

Genbank Nucleotide ID

 AAG53479.1; AAG53480.1; AAG53481.1; AAG53482.1; AAG53483.1; AAT48101.1; ABC00997.1; ABC00998.1; ABC00999.1; ABC01000.1; ABC01001.1; ABC01002.1; ABC01003.1; ABC01004.1; ABC01005.1; ABC01006.1; ABC01007.1; ABC01008.1; ABC01009.1; ABC01010.1; ABC01011.1; ABC01012.1; ABC01013.1; ABC01014.1; ABC01015.1; ABC01016.1; ABC01017.1; ABC01018.1; ABC01019.1; ABC01020.1; ABC01021.1; ABC01022.1; ABC01023.1; ABC01024.1; ABC01025.1; ABC01026.1; ABC01027.1; ABC01028.1; ABC01029.1; ABC01030.1; ABC01031.1; ABC01032.1; ABC01033.1; ABB90543.1; AEN14475.1; AEN14476.1; BAB55218.1; EAW68771.1; EAW68772.1; EAW68774.1; EAW68775.1; ABW96352.1; EAW68776.1; EAW68777.1; AAH21258.1 

Protein Name

 Tripartite motif-containing protein 5 

Protein Synonyms/Alias

 RING finger protein 88 

Gene Name

 TRIM5 

Gene Synonyms/Alias

 RNF88 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
171	REEKASWKTQIQYDK	ubiquitination	[1]
178	KTQIQYDKTNVLADF	ubiquitination	[1]
255	QGVDGVIKRTENVTL	ubiquitination	[1]
282	VFRAPDLKGMLEVFR	ubiquitination	[1]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Capsid-specific restriction factor that prevents infection from non-host-adapted retroviruses. Blocks viral replication early in the life cycle, after viral entry but before reverse transcription. In addition to acting as a capsid-specific restriction factor, also acts as a pattern recognition receptor that activates innate immune signaling in response to the retroviral capsid lattice. Binding to the viral capsid triggers its E3 ubiquitin ligase activity, and in concert with the heterodimeric ubiquitin conjugating enzyme complex UBE2V1-UBE2N (also known as UBC13-UEV1A complex) generates 'Lys-63'-linked polyubiquitin chains, which in turn are catalysts in the autophosphorylation of the MAP3K7/TAK1 complex (includes TAK1, TAB2, and TAB3). Activation of the MAP3K7/TAK1 complex by autophosphorylation results in the induction and expression of NF- kappa-B and MAPK-responsive inflammatory genes, thereby leading to an innate immune response in the infected cell. Restricts infection by N-tropic murine leukemia virus (N-MLV) and equine infectious anemia virus (EIAV). 

Sequence Annotation

 DOMAIN 281 493 B30.2/SPRY.
 ZN_FING 15 59 RING-type.
 ZN_FING 90 132 B box-type.  

Keyword

 3D-structure; Alternative splicing; Antiviral defense; Coiled coil; Complete proteome; Cytoplasm; Host-virus interaction; Immunity; Innate immunity; Ligase; Metal-binding; Polymorphism; Reference proteome; Ubl conjugation; Ubl conjugation pathway; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 493 AA 

Protein Sequence

Gene Ontology

 GO:0000932; C:cytoplasmic mRNA processing body; IDA:UniProtKB.
 GO:0005794; C:Golgi apparatus; IDA:HPA.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0008329; F:signaling pattern recognition receptor activity; IDA:UniProtKB.
 GO:0004842; F:ubiquitin-protein ligase activity; IDA:UniProtKB.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0051607; P:defense response to virus; TAS:UniProtKB.
 GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
 GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; IMP:UniProtKB.
 GO:0043410; P:positive regulation of MAPK cascade; IMP:UniProtKB.
 GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IMP:UniProtKB.
 GO:0070534; P:protein K63-linked ubiquitination; IDA:UniProtKB.
 GO:0070206; P:protein trimerization; IDA:UniProtKB.
 GO:0031664; P:regulation of lipopolysaccharide-mediated signaling pathway; IMP:UniProtKB.
 GO:0019048; P:virus-host interaction; IEA:UniProtKB-KW. 

Interpro

 IPR001870; B30.2/SPRY.
 IPR003879; Butyrophylin.
 IPR008985; ConA-like_lec_gl_sf.
 IPR003877; SPRY_rcpt.
 IPR000315; Znf_B-box.
 IPR001841; Znf_RING.
 IPR013083; Znf_RING/FYVE/PHD.
 IPR017907; Znf_RING_CS. 

Pfam

 PF00622; SPRY
 PF00643; zf-B_box 

SMART

 SM00336; BBOX
 SM00184; RING 

PROSITE

 PS50188; B302_SPRY
 PS50119; ZF_BBOX
 PS00518; ZF_RING_1
 PS50089; ZF_RING_2 

PRINTS

 PR01407; BUTYPHLNCDUF.