UniProt Accession

 F213A_RAT; Q6AXX6; P85300 

Genbank Protein ID

 BC079275 

Genbank Nucleotide ID

 AAH79275.1 

Protein Name

 Redox-regulatory protein FAM213A 

Protein Synonyms/Alias

 Peroxiredoxin-like 2 activated in M-CSF stimulated monocytes; Protein PAMM; Sperm head protein 1 

Gene Name

 Fam213a 

Gene Synonyms/Alias

 Pamm; Shp1 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
55	YLEDIDLKTLEKEPR	acetylation	[1]
101	DLMSLKPKLDELGVP	acetylation	[1]
114	VPLYAVVKEKVKREV	acetylation	[1]
217	LSVLEAVKKIKPQTP	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Involved in redox regulation of the cell. Acts as an antioxidant. Inhibits TNFSF11-induced NFKB1 and JUN activation and osteoclast differentiation. May affect bone resorption and help to maintain bone mass (By similarity). 

Sequence Annotation

 REGION 14 112 Thioredoxin fold (By similarity).
 ACT_SITE 85 85 Redox-active (By similarity).
 ACT_SITE 88 88 Redox-active (By similarity).  

Keyword

 Antioxidant; Complete proteome; Cytoplasm; Redox-active center; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 229 AA 

Protein Sequence

Gene Ontology

 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0016209; F:antioxidant activity; IEA:UniProtKB-KW.
 GO:0055114; P:oxidation-reduction process; IEA:Compara.
 GO:0045670; P:regulation of osteoclast differentiation; IEA:Compara. 

Interpro

 IPR012336; Thioredoxin-like_fold. 

Pfam

  

SMART

  

PROSITE

  

PRINTS