Tag | Content |
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CPLM ID | CPLM-011671 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | ADP/ATP translocase 2 |
Protein Synonyms/Alias | ADP,ATP carrier protein 2; Adenine nucleotide translocator 2; ANT 2; Solute carrier family 25 member 5; ADP/ATP translocase 2, N-terminally processed |
Gene Name | Slc25a5 |
Gene Synonyms/Alias | Ant2 |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
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10 | DAAVSFAKDFLAGGV | acetylation | [1] | 23 | GVAAAISKTAVAPIE | acetylation | [1] | 43 | LQVQHASKQITADKQ | acetylation | [1] | 147 | RLAADVGKAGAEREF | acetylation | [1] | 268 | IARDEGGKAFFKGAW | acetylation | [1] | 272 | EGGKAFFKGAWSNVL | acetylation | [1] |
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Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation (By similarity). |
Sequence Annotation | REPEAT 6 98 Solcar 1. REPEAT 111 201 Solcar 2. REPEAT 212 297 Solcar 3. MOTIF 235 240 Substrate recognition (By similarity). BINDING 80 80 Nucleotide (By similarity). MOD_RES 1 1 N-acetylmethionine (By similarity). MOD_RES 2 2 N-acetylthreonine; in ADP/ATP translocase MOD_RES 23 23 N6-malonyllysine (By similarity). MOD_RES 42 42 Phosphoserine (By similarity). MOD_RES 52 52 N6,N6-dimethyllysine; alternate (By MOD_RES 52 52 N6-methyllysine; alternate (By MOD_RES 92 92 N6-malonyllysine (By similarity). MOD_RES 96 96 N6-malonyllysine (By similarity). MOD_RES 105 105 N6-acetyllysine (By similarity). MOD_RES 147 147 N6-malonyllysine (By similarity). MOD_RES 155 155 N6-acetyllysine (By similarity). MOD_RES 163 163 N6-acetyllysine (By similarity). MOD_RES 166 166 N6-acetyllysine (By similarity). |
Keyword | Acetylation; Chromosome partition; Complete proteome; Direct protein sequencing; Membrane; Methylation; Mitochondrion; Mitochondrion inner membrane; Phosphoprotein; Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 298 AA |
Protein Sequence | MTDAAVSFAK DFLAGGVAAA ISKTAVAPIE RVKLLLQVQH ASKQITADKQ YKGIIDCVVR 60 IPKEQGVLSF WRGNLANVIR YFPTQALNFA FKDKYKQIFL GGVDKRTQFW RYFAGNLASG 120 GAAGATSLCF VYPLDFARTR LAADVGKAGA EREFKGLGDC LVKIYKSDGI KGLYQGFNVS 180 VQGIIIYRAA YFGIYDTAKG MLPDPKNTHI FISWMIAQSV TAVAGLTSYP FDTVRRRMMM 240 QSGRKGTDIM YTGTLDCWRK IARDEGGKAF FKGAWSNVLR GMGGAFVLVL YDEIKKYT 298 |
Gene Ontology | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005743; C:mitochondrial inner membrane; IDA:RGD. GO:0071817; C:MMXD complex; ISS:UniProtKB. GO:0005215; F:transporter activity; IEA:InterPro. GO:0007059; P:chromosome segregation; IEA:UniProtKB-KW. GO:1901029; P:negative regulation of mitochondrial outer membrane permeabilization; ISS:UniProtKB. GO:0008284; P:positive regulation of cell proliferation; ISS:UniProtKB. GO:0055085; P:transmembrane transport; IEA:InterPro. |
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