UniProt Accession

 MYPR_RAT; P60203; P04400; P06905; Q561K5 

Genbank Protein ID

 X02809; M11185; BC093596 

Genbank Nucleotide ID

 CAA26577.1; AAA41898.1; AAH93596.1 

Protein Name

 Myelin proteolipid protein 

Protein Synonyms/Alias

 PLP; Lipophilin 

Gene Name

 Plp1 

Gene Synonyms/Alias

 Plp 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
105	RQIFGDYKTTICGKG	acetylation	[1]
122	ATVTGGQKGRGSRGQ	ubiquitination	[2]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 

Functional Description

 This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin. 

Sequence Annotation

 LIPID 6 6 S-palmitoyl cysteine (By similarity).
 LIPID 7 7 S-palmitoyl cysteine (By similarity).
 LIPID 10 10 S-palmitoyl cysteine (By similarity).
 LIPID 109 109 S-palmitoyl cysteine (By similarity).
 LIPID 139 139 S-palmitoyl cysteine (By similarity).
 LIPID 141 141 S-palmitoyl cysteine (By similarity).
 LIPID 199 199 O-palmitoyl serine (Probable).
 DISULFID 184 228 By similarity.
 DISULFID 201 220 By similarity.  

Keyword

 Complete proteome; Direct protein sequencing; Disease mutation; Disulfide bond; Lipoprotein; Membrane; Palmitate; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 277 AA 

Protein Sequence

Gene Ontology

 GO:0005887; C:integral to plasma membrane; TAS:RGD.
 GO:0043209; C:myelin sheath; IEA:Compara.
 GO:0019911; F:structural constituent of myelin sheath; IMP:RGD.
 GO:0048469; P:cell maturation; IEA:Compara.
 GO:0022010; P:central nervous system myelination; IEA:Compara.
 GO:0010001; P:glial cell differentiation; IMP:RGD.
 GO:0007229; P:integrin-mediated signaling pathway; IPI:RGD.
 GO:0042759; P:long-chain fatty acid biosynthetic process; IEA:Compara.
 GO:0042552; P:myelination; IMP:RGD.
 GO:0010628; P:positive regulation of gene expression; IEA:Compara. 

Interpro

 IPR001614; Myelin_PLP.
 IPR018237; Myelin_PLP_CS. 

Pfam

 PF01275; Myelin_PLP 

SMART

 SM00002; PLP 

PROSITE

 PS00575; MYELIN_PLP_1
 PS01004; MYELIN_PLP_2 

PRINTS

 PR00214; MYELINPLP.