CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-024350
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Muscle-related coiled-coil protein 
Protein Synonyms/Alias
 Muscle-restricted coiled-coil protein 
Gene Name
 Murc 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
12GSASNAGKIHQNRLSubiquitination[1]
52DSVQASQKRIEERHRubiquitination[1]
66REMGNAIKSVQIDLLubiquitination[1]
74SVQIDLLKLSQSHSNubiquitination[1]
88NTGYVVNKLFEKTRKubiquitination[1]
92VVNKLFEKTRKVSAHubiquitination[1]
104SAHIKDVKARVEKQQubiquitination[1]
116KQQVRVTKVETKQEEubiquitination[1]
126TKQEEIMKKNKFRVVubiquitination[1]
149PASLSVVKDRSLPENubiquitination[1]
191ARLRKSGKEHIDHIKubiquitination[1]
265ISSAAPSKEAFKIRSubiquitination[1]
269APSKEAFKIRSLRKAubiquitination[1]
321ETEKEVTKGGYSPQEubiquitination[1]
343EPLKVTFKPQVRVEDubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Induces RHOA activation and activates NPPA transcription and myofibrillar organization through the Rho/ROCK signaling pathway. 
Sequence Annotation
  
Keyword
 Activator; Coiled coil; Complete proteome; Cytoplasm; Developmental protein; Differentiation; Myogenesis; Reference proteome; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 362 AA 
Protein Sequence
MEHNGSASNA GKIHQNRLSS VTEDEDQDAA LTIVTVLDRV ASVVDSVQAS QKRIEERHRE 60
MGNAIKSVQI DLLKLSQSHS NTGYVVNKLF EKTRKVSAHI KDVKARVEKQ QVRVTKVETK 120
QEEIMKKNKF RVVIFQEDIP CPASLSVVKD RSLPENQEEA EEVFDPPIEL SSDEEYYVEE 180
SRSARLRKSG KEHIDHIKKA FSRENMQKTR QTLDKKVSGI RTRIVTPERR ERLRQSGERL 240
RQSGERLRQS GERFKKSISS AAPSKEAFKI RSLRKAKDPK AEGQEVDRGM GVDIISGSLA 300
LGPIHEFHSD EFSETEKEVT KGGYSPQEGG DPPTPEPLKV TFKPQVRVED DESLLLELKQ 360
SS 362 
Gene Ontology
 GO:0030018; C:Z disc; IDA:MGI.
 GO:0005100; F:Rho GTPase activator activity; ISO:MGI.
 GO:0055003; P:cardiac myofibril assembly; ISO:MGI.
 GO:0007517; P:muscle organ development; IEA:UniProtKB-KW.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:MGI.
 GO:0007266; P:Rho protein signal transduction; ISO:MGI.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR026752; Cavin_fam. 
Pfam
  
SMART
  
PROSITE
  
PRINTS