CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-041715
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein kinase, cAMP-dependent, regulatory, type 2, alpha, isoform CRA_a 
Protein Synonyms/Alias
 cAMP-dependent protein kinase type II-alpha regulatory subunit 
Gene Name
 Prkar2a 
Gene Synonyms/Alias
 rCG_25539 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
158AMFEKIVKTDEHVIDacetylation[1]
187TYDILVTKDNQTRSVacetylation[1]
269LEMSERMKIVDVIGEacetylation[1]
342ELALVTNKPRAASAYacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Kinase; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 401 AA 
Protein Sequence
MSHIQIPPGL TELLQGYTVE VLRQQPPDLV DFAVEYFTRL REARRQESDS FIAPPTTFHA 60
QESSGVPVIE EDGESESDSD DEDLEVPIPS KFTRRVSVCA ETFNPDEEED NDPRVVHPKT 120
DEQRCRLQEA CKDILLFKNL DQEQLSQVLD AMFEKIVKTD EHVIDQGDDG DNFYVIERGT 180
YDILVTKDNQ TRSVGQYDNR GSFGELALMY NTPRAATIVA TSDGSLWGLD RVTFRRIIVK 240
NNAKKRKMFE SFIESVPLFK SLEMSERMKI VDVIGEKIYK DGERIITQGE KADSFYIIES 300
GEVSILIRSK TKTNKNGGNQ EVEIAHCHKG QYFGELALVT NKPRAASAYA VGDVKCLVMD 360
VQAFERLLGP CMDIMKRNIS HYEEQLVKMF GSNLDLLDPG Q 401 
Gene Ontology
 GO:0005952; C:cAMP-dependent protein kinase complex; IEA:InterPro.
 GO:0005813; C:centrosome; IEA:Compara.
 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0008603; F:cAMP-dependent protein kinase regulator activity; IEA:InterPro.
 GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
 GO:0007165; P:signal transduction; IEA:InterPro. 
Interpro
 IPR002373; cAMP/cGMP_kin.
 IPR012198; cAMP_dep_PK_reg_su.
 IPR003117; cAMP_dep_PK_reg_su_I/II_a/b.
 IPR018490; cNMP-bd-like.
 IPR018488; cNMP-bd_CS.
 IPR000595; cNMP-bd_dom.
 IPR014710; RmlC-like_jellyroll. 
Pfam
 PF00027; cNMP_binding
 PF02197; RIIa 
SMART
 SM00100; cNMP
 SM00394; RIIa 
PROSITE
 PS00888; CNMP_BINDING_1
 PS00889; CNMP_BINDING_2
 PS50042; CNMP_BINDING_3 
PRINTS
 PR00103; CAMPKINASE.