CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037015
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Heat shock 70 kDa protein 4L 
Protein Synonyms/Alias
  
Gene Name
 HSPA4L 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
84RAIGNAAKSQIVTNVubiquitination[1]
124RLPYELQKMPNGSAGubiquitination[1]
133PNGSAGVKVRYLEEEubiquitination[1]
382ATRIPAVKEQITKFFubiquitination[1]
387AVKEQITKFFLKDISubiquitination[1]
453GECEVFCKNHPAPFSubiquitination[1]
702EDGEDQPKQVYVDKLacetylation[2]
702EDGEDQPKQVYVDKLubiquitination[3]
805KVSEIVAKSKELDNFubiquitination[3]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 870 AA 
Protein Sequence
MSRNPSSNSP EEDTVPVPKG SVPAARPSRG GMSVVGIDLG FLNCYIAVAR SGGIETIANE 60
YSDRCTPACI SLGSRTRAIG NAAKSQIVTN VRNTIHGFKK LHGRSFDDPI VQTERIRLPY 120
ELQKMPNGSA GVKVRYLEEE RPFAIEQVTG MLLAKLKETS ENALKKPVAD CVISIPSFFT 180
DAERRSVMAA AQVAGLNCLR LMNETTAVAL AYGIYKQDLP PLDEKPRNVV FIDMGHSAYQ 240
VLVCAFNKGK LKVLATTFDP YLGGRNFDEA LVDYFCDEFK TKYKINVKEN SRALLRLYQE 300
CEKLKKLMSA NASDLPLNIE CFMNDLDVSS KMNRAQFEQL CASLLARVEP PLKAVMEQAN 360
LQREDISSIE IVGGATRIPA VKEQITKFFL KDISTTLNAD EAVARGCALQ CAILSPAFKV 420
REFSITDLVP YSITLRWKTS FEDGSGECEV FCKNHPAPFS KVITFHKKEP FELEAFYTNL 480
HEVPYPDARI GSFTIQNVFP QSDGDSSKVK VKVRVNIHGI FSVASASVIE KQNLEGDHSD 540
APMETETSFK NENKDNMDKM QVDQEEGHQK CHAEHTPEEE IDHTGAKTKS AVSDKQDRLN 600
QTLKKGKVKS IDLPIQSSLC RQLGQDLLNS YIENEGKMIM QDKLEKERND AKNAVEEYVY 660
DFRDRLGTVY EKFITPEDLS KLSAVLEDTE NWLYEDGEDQ PKQVYVDKLQ ELKKYGQPIQ 720
MKYMEHEERP KALNDLGKKI QLVMKVIEAY RNKDERYDHL DPTEMEKVEK CISDAMSWLN 780
SKMNAQNKLS LTQDPVVKVS EIVAKSKELD NFCNPIIYKP KPKAEVPEDK PKANSEHNGP 840
MDGQSGTETK SDSTKDSSQH TKSSGEMEVD 870 
Gene Ontology
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW. 
Interpro
 IPR018181; Heat_shock_70_CS.
 IPR013126; Hsp_70_fam. 
Pfam
 PF00012; HSP70 
SMART
  
PROSITE
 PS01036; HSP70_3 
PRINTS
 PR00301; HEATSHOCK70.