UniProt Accession

 SAT2_MOUSE; Q6P8J2; Q5F299 

Genbank Protein ID

 AL603707; AL731687; BC061227 

Genbank Nucleotide ID

 CAI51952.1; CAI51952.1; AAH61227.1 

Protein Name

 Diamine acetyltransferase 2 

Protein Synonyms/Alias

 Polyamine N-acetyltransferase 2; Spermidine/spermine N(1)-acetyltransferase 2 

Gene Name

 Sat2 

Gene Synonyms/Alias

 Ssat2 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
29	RELAEFEKLSHQVKI	acetylation	[1, 2]

Reference

 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 

Functional Description

 Enzyme which catalyzes the acetylation of polyamines. Substrate specificity: norspermidine > spermidine = spermine >> N(1)acetylspermine = putrescine (By similarity). 

Sequence Annotation

 DOMAIN 4 166 N-acetyltransferase.
 REGION 27 28 Substrate binding (By similarity).
 REGION 94 96 Acetyl-CoA binding (By similarity).
 REGION 102 107 Acetyl-CoA binding (By similarity).
 REGION 133 135 Acetyl-CoA binding (By similarity).
 BINDING 92 92 Substrate; via carbonyl oxygen (By
 BINDING 140 140 Acetyl-CoA (By similarity).
 BINDING 152 152 Substrate (By similarity).
 MOD_RES 29 29 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Acyltransferase; Complete proteome; Cytoplasm; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 170 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0004145; F:diamine N-acetyltransferase activity; ISA:MGI.
 GO:0009447; P:putrescine catabolic process; IEA:UniProtKB-UniPathway.
 GO:0008216; P:spermidine metabolic process; ISA:MGI.
 GO:0008215; P:spermine metabolic process; ISA:MGI. 

Interpro

 IPR016181; Acyl_CoA_acyltransferase.
 IPR000182; GNAT_dom. 

Pfam

 PF00583; Acetyltransf_1 

SMART

  

PROSITE

 PS51186; GNAT 

PRINTS