| Tag | Content |
|---|
| CPLM ID | CPLM-012799 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Replication protein A 70 kDa DNA-binding subunit |
Protein Synonyms/Alias | RP-A p70; Replication factor A protein 1; RF-A protein 1; Single-stranded DNA-binding protein; DmRPA1 |
Gene Name | RpA-70 |
Gene Synonyms/Alias | RPA1; CG9633 |
Created Date | July 27, 2013 |
Organism | Drosophila melanogaster (Fruit fly) |
NCBI Taxa ID | 7227 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 89 | YVTSLVGKDGAGKRV | acetylation | [1] | | 221 | EIRATAFKEQCDKFY | acetylation | [1] | | 472 | PQSDCNKKVVDEGND | acetylation | [1] |
|
Reference | [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation. Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C. Sci Signal. 2011 Jul 26;4(183):ra48. [ PMID: 21791702] |
Functional Description | Participates in a very early step in DNA replication. RP-A is a single-stranded DNA-binding protein. |
Sequence Annotation | ZN_FING 464 486 C4-type (Potential).
MOD_RES 160 160 Phosphoserine.
MOD_RES 420 420 Phosphoserine. |
Keyword | Complete proteome; DNA replication; DNA-binding; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 603 AA |
Protein Sequence | MVLASLSTGV IARIMHGEVV DAPVLQILAI KKINSAADSE RYRILISDGK YFNSYAMLAS 60
QLNVMQHNGE LEEFTIVQLD KYVTSLVGKD GAGKRVLIIS ELTVVNPGAE VKSKIGEPVT 120
YENAAKQDLA PKPAVTSNSK PIAKKEPSHN NNNNIVMNSS INSGMTHPIS SLSPYQNKWV 180
IKARVTSKSG IRTWSNARGE GKLFSMDLMD ESGEIRATAF KEQCDKFYDL IQVDSVYYIS 240
KCQLKPANKQ YSSLNNAYEM TFSGETVVQL CEDTDDDPIP EIKYNLVPIS DVSGMENKAA 300
VDTIGICKEV GELQSFVART TNKEFKKRDI TLVDMSNSAI SLTLWGDDAV NFDGHVQPVI 360
LVKGTRINEF NGGKSLSLGG GSIMKINPDI PEAHKLRGWF DNGGGDSVAN MVSARTGGGS 420
FSTEWMTLKD ARARNLGSGD KPDYFQCKAV VHIVKQENAF YRACPQSDCN KKVVDEGNDQ 480
FRCEKCNALF PNFKYRLLIN MSIGDWTSNR WVSSFNEVGE QLLGHTSQEV GEALENDPAK 540
AEQIFSALNF TSHIFKLRCK NEVYGDMTRN KLTVQSVAPI NHKEYNKHLL KELQELTGIG 600
SSN 603 |
Gene Ontology | GO:0005662; C:DNA replication factor A complex; IDA:FlyBase. GO:0005875; C:microtubule associated complex; IDA:FlyBase. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0003697; F:single-stranded DNA binding; IDA:FlyBase. GO:0006261; P:DNA-dependent DNA replication; IDA:FlyBase. GO:0007095; P:mitotic G2 DNA damage checkpoint; IGI:FlyBase. GO:0007052; P:mitotic spindle organization; IMP:FlyBase. GO:0048812; P:neuron projection morphogenesis; IMP:FlyBase. |
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Pfam | |
SMART | |
PROSITE | |
PRINTS | |