CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-006830
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein SCO2, mitochondrial 
Protein Synonyms/Alias
  
Gene Name
 SCO2 
Gene Synonyms/Alias
 YBR024W; YBR0308 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
226KSVCKKYKVYFSTPRacetylation[1]
Reference
 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 
Functional Description
 Acts as a copper chaperone, transporting copper to the Cu(A) site on the cytochrome c oxidase subunit II (COX2). 
Sequence Annotation
 DOMAIN 101 284 Thioredoxin.
 METAL 154 154 Copper (By similarity).
 METAL 158 158 Copper (By similarity).
 METAL 245 245 Copper (By similarity).  
Keyword
 Chaperone; Complete proteome; Copper; Membrane; Metal-binding; Mitochondrion; Mitochondrion inner membrane; Reference proteome; Transit peptide; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 301 AA 
Protein Sequence
MLNSSRKYAC RSLFRQANVS IKGLFYNGGA YRRGFSTGCC LRSDNKESPS ARQPLDRLQL 60
GDEINEPEPI RTRFFQFSRW KATIALLLLS GGTYAYLSRK RRLLETEKEA DANRAYGSVA 120
LGGPFNLTDF NGKPFTEENL KGKFSILYFG FSHCPDICPE ELDRLTYWIS ELDDKDHIKI 180
QPLFISCDPA RDTPDVLKEY LSDFHPAIIG LTGTYDQVKS VCKKYKVYFS TPRDVKPNQD 240
YLVDHSIFFY LIDPEGQFID ALGRNYDEQS GLEKIREQIQ AYVPKEERER RSKKWYSFIF 300
N 301 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005740; C:mitochondrial envelope; IDA:SGD.
 GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
 GO:0005507; F:copper ion binding; IEA:InterPro.
 GO:0008379; F:thioredoxin peroxidase activity; ISS:SGD.
 GO:0006878; P:cellular copper ion homeostasis; IEA:InterPro.
 GO:0006825; P:copper ion transport; ISS:SGD.
 GO:0008535; P:respiratory chain complex IV assembly; IEA:InterPro. 
Interpro
 IPR003782; SCO1/SenC.
 IPR017276; Synth_of_cyt-c-oxidase_Sco1/2.
 IPR012336; Thioredoxin-like_fold. 
Pfam
 PF02630; SCO1-SenC 
SMART
  
PROSITE
 PS51352; THIOREDOXIN_2 
PRINTS