UniProt Accession

 TECR_RAT; Q64232 

Genbank Protein ID

 S45663; BC059115 

Genbank Nucleotide ID

 AAB23534.1; AAH59115.1 

Protein Name

 Very-long-chain enoyl-CoA reductase 

Protein Synonyms/Alias

 Synaptic glycoprotein SC2; Trans-2,3-enoyl-CoA reductase; TER 

Gene Name

 Tecr 

Gene Synonyms/Alias

 Gpsn2 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
2	******MKHYEVEIR	acetylation	[1]
22	EKLCFLDKVEPQATI	acetylation	[1]
38	EIKTLFTKTHPQWYP	acetylation	[1]
60	DPKGKSLKDEDVLQK	acetylation	[1]
291	GKHRSYLKEFRDYPP	acetylation	[1]
291	GKHRSYLKEFRDYPP	ubiquitination	[2]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 

Functional Description

 Reduces trans-2,3-stearoyl-CoA to stearoyl-CoA of long and very long chain fatty acids (By similarity). 

Sequence Annotation

 MOD_RES 22 22 N6-acetyllysine (By similarity).
 MOD_RES 116 116 N6-acetyllysine (By similarity).
 CARBOHYD 164 164 N-linked (GlcNAc...) (Potential).
 CARBOHYD 247 247 N-linked (GlcNAc...) (Potential).  

Keyword

 Acetylation; Complete proteome; Endoplasmic reticulum; Glycoprotein; Lipid biosynthesis; Lipid metabolism; Membrane; NADP; Oxidoreductase; Reference proteome; Steroid biosynthesis; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 308 AA 

Protein Sequence

Gene Ontology

 GO:0030176; C:integral to endoplasmic reticulum membrane; ISS:UniProtKB.
 GO:0016627; F:oxidoreductase activity, acting on the CH-CH group of donors; IEA:InterPro.
 GO:0030497; P:fatty acid elongation; ISS:UniProtKB.
 GO:0006694; P:steroid biosynthetic process; IEA:UniProtKB-KW.
 GO:0042761; P:very long-chain fatty acid biosynthetic process; ISS:UniProtKB. 

Interpro

 IPR001104; 3-oxo-5_a-steroid_4-DH_C. 

Pfam

 PF02544; Steroid_dh 

SMART

  

PROSITE

 PS50244; S5A_REDUCTASE 

PRINTS