Tag | Content |
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CPLM ID | CPLM-009579 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Ras-related protein Rap-1A |
Protein Synonyms/Alias | Ras-related protein Krev-1 |
Gene Name | Rap1a |
Gene Synonyms/Alias | Krev1 |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
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5 | ***MREYKLVVLGSG | acetylation | [1] | 151 | LESSAKSKINVNEIF | acetylation | [1] |
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Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Induces morphological reversion of a cell line transformed by a Ras oncogene. Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner. Together with ITGB1BP1, regulates KRIT1 localization to microtubules and membranes (By similarity). |
Sequence Annotation | NP_BIND 10 17 GTP (By similarity). NP_BIND 57 61 GTP (By similarity). NP_BIND 116 119 GTP (By similarity). MOTIF 32 40 Effector region (Probable). MOD_RES 181 181 Cysteine methyl ester (By similarity). LIPID 181 181 S-geranylgeranyl cysteine (By |
Keyword | Cell membrane; Complete proteome; GTP-binding; Lipoprotein; Membrane; Methylation; Nucleotide-binding; Prenylation; Reference proteome; Tumor suppressor. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 184 AA |
Protein Sequence | MREYKLVVLG SGGVGKSALT VQFVQGIFVE KYDPTIEDSY RKQVEVDCQQ CMLEILDTAG 60 TEQFTAMRDL YMKNGQGFAL VYSITAQSTF NDLQDLREQI LRVKDTEDVP MILVGNKCDL 120 EDERVVGKEQ GQNLARQWCN CAFLESSAKS KINVNEIFYD LVRQINRKTP VEKKKPKKKS 180 CLLL 184 |
Gene Ontology | GO:0005829; C:cytosol; TAS:Reactome. GO:0032045; C:guanyl-nucleotide exchange factor complex; IEA:Compara. GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. GO:0005525; F:GTP binding; IEA:UniProtKB-KW. GO:0003924; F:GTPase activity; IEA:Compara. GO:0032403; F:protein complex binding; ISS:UniProtKB. GO:0008565; F:protein transporter activity; ISS:UniProtKB. GO:0007264; P:small GTPase mediated signal transduction; IEA:Compara. |
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