| Tag | Content |
|---|
| CPLM ID | CPLM-001991 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Apolipoprotein A-IV |
Protein Synonyms/Alias | Apo-AIV; ApoA-IV; Apolipoprotein A4 |
Gene Name | Apoa4 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 119 | NMMPHANKVSQMFGD | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons. |
Sequence Annotation | REPEAT 33 54 1.
REPEAT 60 81 2.
REPEAT 82 103 3.
REPEAT 115 136 4.
REPEAT 137 158 5.
REPEAT 159 180 6.
REPEAT 181 202 7.
REPEAT 203 224 8.
REPEAT 225 246 9.
REPEAT 247 268 10.
REPEAT 269 286 11.
REPEAT 287 308 12.
REPEAT 309 330 13.
REGION 33 330 13 X 22 AA approximate tandem repeats. |
Keyword | Chylomicron; Complete proteome; HDL; Lipid transport; Reference proteome; Repeat; Secreted; Signal; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 391 AA |
Protein Sequence | MFLKAVVLTV ALVAITGTQA EVTSDQVANV MWDYFTQLSN NAKEAVEQLQ KTDVTQQLNT 60
LFQDKLGNIN TYADDLQNKL VPFAVQLSGH LTKETERVRE EIQKELEDLR ANMMPHANKV 120
SQMFGDNVQK LQEHLRPYAT DLQAQINAQT QDMKRQLTPY IQRMQTTIQD NVENLQSSMV 180
PFANELKEKF NQNMEGLKGQ LTPRANELKA TIDQNLEDLR SRLAPLAEGV QEKLNHQMEG 240
LAFQMKKNAE ELQTKVSTNI DQLQKNLAPL VEDVQSKLKG NTEGLQKSLE DLNKQLDQQV 300
EVFRRAVEPL GDKFNMALVQ QMEKFRQQLG SDSGDVESHL SFLEKNLREK VSSFMSTLQK 360
KGSPDQPLAL PLPEQVQEQV QEQVQPKPLE S 391 |
Gene Ontology | GO:0042627; C:chylomicron; IDA:RGD. GO:0034364; C:high-density lipoprotein particle; IEA:UniProtKB-KW. GO:0008289; F:lipid binding; IEA:InterPro. GO:0006869; P:lipid transport; TAS:RGD. GO:0042157; P:lipoprotein metabolic process; IEA:InterPro. GO:0014012; P:peripheral nervous system axon regeneration; IEP:RGD. GO:0032094; P:response to food; TAS:RGD. GO:0034014; P:response to triglyceride; IEP:RGD. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |