CPLM-000737

Genbank Nucleotide ID

Neuronal migration protein doublecortin

Protein Synonyms/Alias

Doublin; Lissencephalin-X; Lis-X

Homo sapiens (Human)

Position	Peptide	Type	References
131	LQALSNEKKAKKVRF	acetylation	[1]
132	QALSNEKKAKKVRFY	acetylation	[1]

[1] Regulation of cellular metabolism by protein lysine acetylation.
Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786]

Functional Description

Microtubule-associated protein required for initial steps of neuronal dispersion and cortex lamination during cerebral cortex development. May act by competing with the putative neuronal protein kinase DCLK1 in binding to a target protein. May in that way participate in a signaling pathway that is crucial for neuronal interaction before and during migration, possibly as part of a calcium ion-dependent signal transduction pathway. May be part with PAFAH1B1/LIS-1 of overlapping, but distinct, signaling pathways that promote neuronal migration.

DOMAIN 134 220 Doublecortin 1.
DOMAIN 261 344 Doublecortin 2.
MOD_RES 95 95 Phosphothreonine; by PKC (Potential).
MOD_RES 109 109 Phosphoserine; by CDK5 (By similarity).
MOD_RES 128 128 Phosphoserine; by MARK1 and PKA (By
MOD_RES 151 151 Phosphotyrosine; by ABL (Potential).
MOD_RES 155 155 Phosphoserine; by PKC (Potential).
MOD_RES 171 171 Phosphoserine; by CK2 (Potential).
MOD_RES 191 191 Phosphoserine; by PKC (Potential).
MOD_RES 196 196 Phosphoserine; by CK2, MARK1 and PKA (By
MOD_RES 346 346 Phosphoserine; by CK2 (By similarity).
MOD_RES 368 368 Phosphoserine; by CDK5 (By similarity).
MOD_RES 370 370 Phosphothreonine; by CDK5 (By
MOD_RES 375 375 Phosphoserine; by PKC (Potential).
MOD_RES 378 378 Phosphoserine; by CDK5 (By similarity).
MOD_RES 385 385 Phosphoserine (By similarity).
MOD_RES 387 387 Phosphoserine; by CK2; alternate
MOD_RES 387 387 Phosphoserine; by DYRK2; alternate.
MOD_RES 398 398 Phosphoserine (By similarity).
MOD_RES 402 402 Phosphothreonine; by CDK5; alternate (By
MOD_RES 402 402 Phosphothreonine; by PKC and MAPK;
MOD_RES 408 408 Phosphoserine; by CDK5; alternate (By
MOD_RES 408 408 Phosphoserine; by MAPK; alternate
MOD_RES 412 412 Phosphothreonine; by MAPK (Potential).
MOD_RES 415 415 Phosphoserine; by CDK5; alternate (By
MOD_RES 415 415 Phosphoserine; by MAPK; alternate
MOD_RES 418 418 Phosphoserine; by PKC (Potential).
MOD_RES 430 430 Phosphoserine; by CK2 (Potential).
MOD_RES 436 436 Phosphoserine; by CK2 (Potential).

3D-structure; Alternative splicing; Cell projection; Chromosomal rearrangement; Complete proteome; Cytoplasm; Developmental protein; Differentiation; Disease mutation; Epilepsy; Lissencephaly; Microtubule; Neurogenesis; Phosphoprotein; Reference proteome; Repeat.

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

GO:0005829; C:cytosol; TAS:Reactome.
GO:0005874; C:microtubule; IEA:UniProtKB-KW.
GO:0005875; C:microtubule associated complex; TAS:ProtInc.
GO:0043005; C:neuron projection; IDA:UniProtKB.
GO:0008017; F:microtubule binding; IDA:UniProtKB.
GO:0048675; P:axon extension; IEA:Compara.
GO:0007411; P:axon guidance; TAS:Reactome.
GO:0007420; P:brain development; IEA:Compara.
GO:0007417; P:central nervous system development; TAS:ProtInc.
GO:0021952; P:central nervous system projection neuron axonogenesis; IEA:Compara.
GO:0048813; P:dendrite morphogenesis; IEA:Compara.
GO:0035556; P:intracellular signal transduction; IEA:InterPro.
GO:0001764; P:neuron migration; IDA:UniProtKB.

IPR017302; Doublecortin_chordata.
IPR003533; Doublecortin_dom.