UniProt Accession

 NRK1_MOUSE; Q91W63; Q3TDW3 

Genbank Protein ID

 AK050579; AK169962; BC016495 

Genbank Nucleotide ID

 BAC34328.1; BAE41485.1; AAH16495.1 

Protein Name

 Nicotinamide riboside kinase 1 

Protein Synonyms/Alias

 NRK 1; NmR-K 1; Nicotinic acid riboside kinase 1; Ribosylnicotinamide kinase 1; RNK 1; Ribosylnicotinic acid kinase 1 

Gene Name

 Nmrk1 

Gene Synonyms/Alias

 Nrk1 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
16	GGVTNGGKTTLAKSL	ubiquitination	[1]
126	TVPYEECKRRRSTRV	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN) (By similarity). 

Sequence Annotation

 NP_BIND 10 18 ATP (By similarity).
 NP_BIND 172 174 ATP (By similarity).
 ACT_SITE 36 36 Proton acceptor (By similarity).
 METAL 17 17 Magnesium (By similarity).
 METAL 36 36 Magnesium (By similarity).
 BINDING 56 56 Substrate (By similarity).
 BINDING 128 128 ATP (By similarity).
 BINDING 129 129 Substrate (By similarity).
 BINDING 132 132 ATP (By similarity).  

Keyword

 ATP-binding; Complete proteome; Kinase; Magnesium; Metal-binding; Nucleotide-binding; Pyridine nucleotide biosynthesis; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 195 AA 

Protein Sequence

Gene Ontology

 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0050262; F:ribosylnicotinamide kinase activity; IEA:EC.
 GO:0009435; P:NAD biosynthetic process; IEA:UniProtKB-UniPathway. 

Interpro

 IPR027417; P-loop_NTPase. 

Pfam

  

SMART

  

PROSITE

  

PRINTS