UniProt Accession

 FEM1C_HUMAN; Q96JP0; B2RE47; Q8N3V8; Q9H704; Q9NPL6; Q9NPL9 

Genbank Protein ID

 AF391093; AY249188; AB058688; AK025265; AK315803; CH471086; BC028369; AL365409; AL365415; AL831817 

Genbank Nucleotide ID

 AAL37627.1; AAO64429.1; BAB47414.1; BAB15096.1; BAG38144.1; EAW48963.1; AAH28369.1; CAB96953.1; CAB96957.1; CAD38531.1 

Protein Name

 Protein fem-1 homolog C 

Protein Synonyms/Alias

 FEM1c; FEM1-gamma 

Gene Name

 FEM1C 

Gene Synonyms/Alias

 KIAA1785 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
4	****MDLKTAVFNAA	ubiquitination	[1]
267	RDLLGALKYWKKAMN	ubiquitination	[2]
286	DRTNIISKPVPQTLI	ubiquitination	[1]
355	YADSGNFKRCINLWK	ubiquitination	[1]
474	QTIYRFLKLHPRGKN	ubiquitination	[1]
571	ASDLLDEKEIAKNLI	ubiquitination	[3]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Probable component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit (By similarity). 

Sequence Annotation

 REPEAT 2 31 ANK 1.
 REPEAT 40 70 ANK 2.
 REPEAT 82 111 ANK 3.
 REPEAT 115 144 ANK 4.
 REPEAT 148 177 ANK 5.
 REPEAT 181 210 ANK 6.
 REPEAT 213 242 ANK 7.
 REPEAT 245 279 TPR 1.
 REPEAT 338 371 TPR 2.
 REPEAT 481 523 ANK 8.
 REPEAT 527 556 ANK 9.  

Keyword

 ANK repeat; Complete proteome; Cytoplasm; Polymorphism; Reference proteome; Repeat; TPR repeat; Ubl conjugation pathway. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 617 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway. 

Interpro

 IPR002110; Ankyrin_rpt.
 IPR020683; Ankyrin_rpt-contain_dom. 

Pfam

 PF00023; Ank
 PF12796; Ank_2 

SMART

 SM00248; ANK 

PROSITE

 PS50297; ANK_REP_REGION
 PS50088; ANK_REPEAT
 PS50005; TPR
 PS50293; TPR_REGION 

PRINTS

 PR01415; ANKYRIN.