CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-000694
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 WD repeat-containing protein 62 
Protein Synonyms/Alias
  
Gene Name
 WDR62 
Gene Synonyms/Alias
 C19orf14 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
452SPDSHWQKNIFSNTLubiquitination[1]
492NGTPMDVKAGVRVMQubiquitination[1, 2]
587SSSITAIKFAGNRDIubiquitination[1]
603MISCGADKSIYFRSAubiquitination[1]
667GKQKKCYKGSQGDEGubiquitination[2]
832RCLLTNGKLPLWAKRubiquitination[1]
838GKLPLWAKRLLGDDDubiquitination[1]
855DGLAFHAKRSYQPHGubiquitination[1, 2]
961TDSQYCRKEVEAGPGubiquitination[1, 2]
1122RATQCLVKSPEVKLMubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
 Required for cerebral cortical development. Plays a role in neuronal proliferation and migration. 
Sequence Annotation
 REPEAT 109 150 WD 1.
 REPEAT 153 194 WD 2.
 REPEAT 196 234 WD 3.
 REPEAT 291 330 WD 4.
 REPEAT 357 396 WD 5.
 REPEAT 402 450 WD 6.
 REPEAT 490 529 WD 7.
 REPEAT 532 574 WD 8.
 REPEAT 578 618 WD 9.
 REPEAT 626 665 WD 10.
 REPEAT 671 713 WD 11.
 REPEAT 714 752 WD 12.
 REPEAT 803 846 WD 13.
 REPEAT 1132 1173 WD 14.
 REPEAT 1255 1293 WD 15.
 MOD_RES 2 2 N-acetylalanine.
 MOD_RES 46 46 Phosphothreonine.
 MOD_RES 49 49 Phosphoserine.
 MOD_RES 50 50 Phosphothreonine.
 MOD_RES 52 52 Phosphoserine.
 MOD_RES 501 501 Phosphoserine.
 MOD_RES 1053 1053 Phosphothreonine.
 MOD_RES 1093 1093 Phosphoserine.
 MOD_RES 1101 1101 Phosphoserine.
 MOD_RES 1123 1123 Phosphoserine.
 MOD_RES 1228 1228 Phosphoserine.
 MOD_RES 1248 1248 Phosphoserine.
 MOD_RES 1249 1249 Phosphoserine.
 MOD_RES 1268 1268 Phosphothreonine.  
Keyword
 Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Cytoskeleton; Disease mutation; Mental retardation; Neurogenesis; Nucleus; Phosphoprotein; Polymorphism; Primary microcephaly; Reference proteome; Repeat; WD repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1518 AA 
Protein Sequence
MAAVGSGGYA RNDAGEKLPS VMAGVPARRG QSSPPPAPPI CLRRRTRLST ASEETVQNRV 60
SLEKVLGITA QNSSGLTCDP GTGHVAYLAG CVVVILDPKE NKQQHIFNTA RKSLSALAFS 120
PDGKYIVTGE NGHRPAVRIW DVEEKNQVAE MLGHKYGVAC VAFSPNMKHI VSMGYQHDMV 180
LNVWDWKKDI VVASNKVSCR VIALSFSEDS SYFVTVGNRH VRFWFLEVST ETKVTSTVPL 240
VGRSGILGEL HNNIFCGVAC GRGRMAGSTF CVSYSGLLCQ FNEKRVLEKW INLKVSLSSC 300
LCVSQELIFC GCTDGIVRIF QAHSLHYLAN LPKPHYLGVD VAQGLEPSFL FHRKAEAVYP 360
DTVALTFDPI HQWLSCVYKD HSIYIWDVKD INRVGKVWSE LFHSSYVWNV EVYPEFEDQR 420
ACLPSGSFLT CSSDNTIRFW NLDSSPDSHW QKNIFSNTLL KVVYVENDIQ HLQDMSHFPD 480
RGSENGTPMD VKAGVRVMQV SPDGQHLASG DRSGNLRIHE LHFMDELVKV EAHDAEVLCL 540
EYSKPETGLT LLASASRDRL IHVLNVEKNY NLEQTLDDHS SSITAIKFAG NRDIQMISCG 600
ADKSIYFRSA QQGSDGLHFV RTHHVAEKTT LYDMDIDITQ KYVAVACQDR NVRVYNTVNG 660
KQKKCYKGSQ GDEGSLLKVH VDPSGTFLAT SCSDKSISVI DFYSGECIAK MFGHSEIITS 720
MKFTYDCHHL ITVSGDSCVF IWHLGPEITN CMKQHLLEID HRQQQQHTND KKRSGHPRQD 780
TYVSTPSEIH SLSPGEQTED DLEEECEPEE MLKTPSKDSL DPDPRCLLTN GKLPLWAKRL 840
LGDDDVADGL AFHAKRSYQP HGRWAERAGQ EPLKTILDAQ DLDCYFTPMK PESLENSILD 900
SLEPQSLASL LSESESPQEA GRGHPSFLPQ QKESSEASEL ILYSLEAEVT VTGTDSQYCR 960
KEVEAGPGDQ QGDSYLRVSS DSPKDQSPPE DSGESEADLE CSFAAIHSPA PPPDPAPRFA 1020
TSLPHFPGCA GPTEDELSLP EGPSVPSSSL PQTPEQEKFL RHHFETLTES PCRALGDVEA 1080
SEAEDHFFNP RLSISTQFLS SLQKASRFTH TFPPRATQCL VKSPEVKLMD RGGSQPRAGT 1140
GYASPDRTHV LAAGKAEETL EAWRPPPPCL TSLASCVPAS SVLPTDRNLP TPTSAPTPGL 1200
AQGVHAPSTC SYMEATASSR ARISRSISLG DSEGPIVATL AQPLRRPSSV GELASLGQEL 1260
QAITTATTPS LDSEGQEPAL RSWGNHEARA NLRLTLSSAC DGLLQPPVDT QPGVTVPAVS 1320
FPAPSPVEES ALRLHGSAFR PSLPAPESPG LPAHPSNPQL PEARPGIPGG TASLLEPTSG 1380
ALGLLQGSPA RWSEPWVPVE ALPPSPLELS RVGNILHRLQ TTFQEALDLY RVLVSSGQVD 1440
TGQQQARTEL VSTFLWIHSQ LEAECLVGTS VAPAQALPSP GPPSPPTLYP LASPDLQALL 1500
EHYSELLVQA VRRKARGH 1518 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0000922; C:spindle pole; IDA:UniProtKB.
 GO:0021987; P:cerebral cortex development; IMP:UniProtKB.
 GO:0022008; P:neurogenesis; IMP:UniProtKB. 
Interpro
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR017986; WD40_repeat_dom. 
Pfam
 PF00400; WD40 
SMART
 SM00320; WD40 
PROSITE
 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 
PRINTS