UniProt Accession

 DAZ2_HUMAN; Q13117; Q2KHN6; Q96P41; Q9NR91 

Genbank Protein ID

 U21663; AF248480; AF414184; AC006338; BC113006 

Genbank Nucleotide ID

 AAB02393.1; AAF91329.1; AAL24502.1; AAI13007.1 

Protein Name

 Deleted in azoospermia protein 2 

Protein Synonyms/Alias

  

Gene Name

 DAZ2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
36	GWVLPEGKIVPNTVF	ubiquitination	[1]
67	FGRYGSVKEVKIITN	ubiquitination	[1]
80	TNRTGVSKGYGFVSF	ubiquitination	[1]
95	VNDVDVQKIVGSQIH	ubiquitination	[1]
106	SQIHFHGKKLKLGPA	ubiquitination	[1]
107	QIHFHGKKLKLGPAI	ubiquitination	[1]
116	KLGPAIRKQKLCARH	ubiquitination	[1]
118	GPAIRKQKLCARHVQ	ubiquitination	[1]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3'-UTR of mRNAs and regulating their translation. 

Sequence Annotation

 DOMAIN 40 115 RRM.
 DOMAIN 170 190 DAZ-like 1.
 DOMAIN 194 214 DAZ-like 2.
 DOMAIN 218 238 DAZ-like 3.
 DOMAIN 242 262 DAZ-like 4.
 DOMAIN 266 286 DAZ-like 5.
 DOMAIN 290 310 DAZ-like 6.
 DOMAIN 314 334 DAZ-like 7.
 DOMAIN 338 358 DAZ-like 8.
 DOMAIN 362 382 DAZ-like 9.
 DOMAIN 386 406 DAZ-like 10.
 DOMAIN 410 430 DAZ-like 11.
 DOMAIN 434 454 DAZ-like 12.
 DOMAIN 458 478 DAZ-like 13.
 DOMAIN 482 502 DAZ-like 14.
 DOMAIN 506 526 DAZ-like 15.  

Keyword

 Alternative splicing; Complete proteome; Cytoplasm; Developmental protein; Differentiation; Nucleus; Reference proteome; Repeat; RNA-binding; Spermatogenesis. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 558 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0003723; F:RNA binding; TAS:ProtInc.
 GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
 GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.
 GO:0007338; P:single fertilization; TAS:ProtInc.
 GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW. 

Interpro

 IPR012677; Nucleotide-bd_a/b_plait.
 IPR000504; RRM_dom. 

Pfam

 PF00076; RRM_1 

SMART

 SM00360; RRM 

PROSITE

 PS50102; RRM 

PRINTS