CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-041190
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Heterogeneous nuclear ribonucleoprotein L 
Protein Synonyms/Alias
  
Gene Name
 Hnrnpl 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
96QRIVIFRKNGVQAMVubiquitination[1]
136TLKIEYAKPTRLNVFubiquitination[1]
169DPGSNPNKRQRQPPLubiquitination[1]
278CLYGNVEKVKFMKSKacetylation[2]
285KVKFMKSKPGAAMVEubiquitination[1]
322KMNVCVSKQPAIMPGacetylation[2]
342EDGSCSYKDFSESRNacetylation[2, 3]
360STPEQAAKNRIQHPSubiquitination[1]
400VKRPTSVKVFSGKSEubiquitination[1]
405SVKVFSGKSERSSSGacetylation[3]
435FLNHYQMKNPNGPYPubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 456 AA 
Protein Sequence
MPKKRQALVE FEDVLGACNA VNYAADNQIY IAGHPAFVNY STSQKISRPG DSDDSRSVNS 60
VLLFTILNPI YSITTDVLYT ICNPCGPVQR IVIFRKNGVQ AMVEFDSVQS AQRAKASLNG 120
ADIYSGCCTL KIEYAKPTRL NVFKNDQDTW DYTNPNLSGQ GDPGSNPNKR QRQPPLLGDH 180
PAEYGGPHGG YHSHYHDEGY GPPPPHYEGR RMGPPVGGHR RGPSRYGPQY GHPPPPPPPP 240
DYGPHADSPV LMVYGLDQSK MNCDRVFNVF CLYGNVEKVK FMKSKPGAAM VEMADGYAVD 300
RAITHLNNNF MFGQKMNVCV SKQPAIMPGQ SYGLEDGSCS YKDFSESRNN RFSTPEQAAK 360
NRIQHPSNVL HFFNAPLEVT EENFFEICDE LGVKRPTSVK VFSGKSERSS SGLLEWDSKS 420
DALETLGFLN HYQMKNPNGP YPYTLKLCFS TAQHAS 456 
Gene Ontology
 GO:0045120; C:pronucleus; IDA:MGI.
 GO:0030529; C:ribonucleoprotein complex; IEA:Compara.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0003723; F:RNA binding; IEA:InterPro.
 GO:0044212; F:transcription regulatory region DNA binding; IEA:Compara.
 GO:0006397; P:mRNA processing; IEA:InterPro. 
Interpro
 IPR006536; HnRNP-L_PTB.
 IPR012677; Nucleotide-bd_a/b_plait.
 IPR000504; RRM_dom. 
Pfam
  
SMART
 SM00360; RRM 
PROSITE
 PS50102; RRM 
PRINTS