UniProt Accession

 PRS8_RAT; P62198; O35051; P47210; P52915; P52916 

Genbank Protein ID

 D83521; AB000491; AB000493; BC058462 

Genbank Nucleotide ID

 BAA11938.1; BAA22933.1; BAA22935.1; AAH58462.1 

Protein Name

 26S protease regulatory subunit 8 

Protein Synonyms/Alias

 26S proteasome AAA-ATPase subunit RPT6; Proteasome 26S subunit ATPase 5; Proteasome subunit p45; Thyroid hormone receptor-interacting protein 1; TRIP1; p45/SUG 

Gene Name

 Psmc5 

Gene Synonyms/Alias

 Sug1 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
88	DKKKVLVKVHPEGKF	acetylation	[1]
222	SGSELVQKFIGEGAR	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex. 

Sequence Annotation

 NP_BIND 190 197 ATP (Potential).
 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 222 222 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; ATP-binding; Complete proteome; Cytoplasm; Nucleotide-binding; Nucleus; Proteasome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 406 AA 

Protein Sequence

Gene Ontology

 GO:0031410; C:cytoplasmic vesicle; IEA:Compara.
 GO:0031597; C:cytosolic proteasome complex; IDA:RGD.
 GO:0016234; C:inclusion body; IDA:RGD.
 GO:0031595; C:nuclear proteasome complex; IDA:RGD.
 GO:0022624; C:proteasome accessory complex; ISS:UniProtKB.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0016887; F:ATPase activity; IDA:RGD.
 GO:0031531; F:thyrotropin-releasing hormone receptor binding; ISS:UniProtKB.
 GO:0008134; F:transcription factor binding; ISS:UniProtKB.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; IEA:Compara.
 GO:0090261; P:positive regulation of inclusion body assembly; IMP:RGD.
 GO:0043161; P:proteasomal ubiquitin-dependent protein catabolic process; ISS:UniProtKB. 

Interpro

 IPR005937; 26S_Psome_P45.
 IPR003593; AAA+_ATPase.
 IPR003959; ATPase_AAA_core.
 IPR003960; ATPase_AAA_CS.
 IPR027417; P-loop_NTPase. 

Pfam

 PF00004; AAA 

SMART

 SM00382; AAA 

PROSITE

 PS00674; AAA 

PRINTS