UniProt Accession

 A2APS4_MOUSE; A2APS4 

Genbank Protein ID

 AL844206 

Genbank Nucleotide ID

  

Protein Name

 Non-specific lipid-transfer protein 

Protein Synonyms/Alias

  

Gene Name

 Scp2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
7	*MPSVALKSPRLRRV	acetylation	[1, 2]
7	*MPSVALKSPRLRRV	ubiquitination	[3]
23	VVGVGMTKFMKPGGE	acetylation	[4]
23	VVGVGMTKFMKPGGE	succinylation	[4]
23	VVGVGMTKFMKPGGE	ubiquitination	[3]
26	VGMTKFMKPGGENSR	acetylation	[2, 4]
26	VGMTKFMKPGGENSR	succinylation	[4]
26	VGMTKFMKPGGENSR	ubiquitination	[3]
40	RDYPDMAKEAGQKAL	acetylation	[2, 4, 5]
40	RDYPDMAKEAGQKAL	succinylation	[4]
40	RDYPDMAKEAGQKAL	ubiquitination	[3]
88	ERGSIGTKFSDRTTP	acetylation	[1, 2, 4, 5, 6, 7]
88	ERGSIGTKFSDRTTP	succinylation	[4]
88	ERGSIGTKFSDRTTP	ubiquitination	[3]
98	DRTTPTDKHIEVLID	acetylation	[2]
98	DRTTPTDKHIEVLID	ubiquitination	[3]
106	HIEVLIDKYGLSAHP	ubiquitination	[3]
124	QMFGYAGKEHMEKYG	acetylation	[4]
124	QMFGYAGKEHMEKYG	succinylation	[4]
124	QMFGYAGKEHMEKYG	ubiquitination	[3]
129	AGKEHMEKYGTKVEH	acetylation	[2, 4]
129	AGKEHMEKYGTKVEH	succinylation	[4]
129	AGKEHMEKYGTKVEH	ubiquitination	[3]
133	HMEKYGTKVEHFAKI	acetylation	[1, 2, 4, 5]
133	HMEKYGTKVEHFAKI	succinylation	[4]
133	HMEKYGTKVEHFAKI	ubiquitination	[3]
139	TKVEHFAKIGWKNHK	acetylation	[1, 2, 4]
139	TKVEHFAKIGWKNHK	succinylation	[4]
139	TKVEHFAKIGWKNHK	ubiquitination	[3]
146	KIGWKNHKHSVNNTY	ubiquitination	[3]
167	YSLEEVMKSKPVFDF	acetylation	[4]
167	YSLEEVMKSKPVFDF	succinylation	[4]
167	YSLEEVMKSKPVFDF	ubiquitination	[3]

Reference

 [1] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753]
 [2] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
 [3] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [4] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [5] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
 [6] Mitochondrial acetylome analysis in a mouse model of alcohol-induced liver injury utilizing SIRT3 knockout mice.
 Fritz KS, Galligan JJ, Hirschey MD, Verdin E, Petersen DR.
 J Proteome Res. 2012 Mar 2;11(3):1633-43. [PMID: 22309199]
 [7] Circadian acetylome reveals regulation of mitochondrial metabolic pathways.
 Masri S, Patel VR, Eckel-Mahan KL, Peleg S, Forne I, Ladurner AG, Baldi P, Imhof A, Sassone-Corsi P.
 Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3339-44. [PMID: 23341599] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 231 AA 

Protein Sequence

Gene Ontology

 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0005777; C:peroxisome; TAS:MGI.
 GO:0050632; F:propionyl-CoA C2-trimethyltridecanoyltransferase activity; TAS:MGI.
 GO:0006637; P:acyl-CoA metabolic process; TAS:MGI.
 GO:0007031; P:peroxisome organization; IMP:MGI. 

Interpro

 IPR016039; Thiolase-like.
 IPR016038; Thiolase-like_subgr. 

Pfam

  

SMART

  

PROSITE

  

PRINTS