UniProt Accession

 NDUB7_HUMAN; P17568; Q6ICN9; Q9UI16 

Genbank Protein ID

 M33374; AF217091; AF112200; CR450354; CH471106; BC002595 

Genbank Nucleotide ID

 AAA35675.1; AAF91223.1; AAF17188.1; CAG29350.1; EAW84436.1; AAH02595.1 

Protein Name

 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 

Protein Synonyms/Alias

 Cell adhesion protein SQM1; Complex I-B18; CI-B18; NADH-ubiquinone oxidoreductase B18 subunit 

Gene Name

 NDUFB7 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
81	FPNFLACKQERHDWD	ubiquitination	[1, 2]
100	RDYVMRMKEFERERR	ubiquitination	[1]
124	KKAAELAKGQGPGEV	ubiquitination	[1, 3]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. 

Sequence Annotation

 MOTIF 59 69 C-X9-C motif 1.
 MOTIF 80 90 C-X9-C motif 2.
 LIPID 2 2 N-myristoyl glycine (By similarity).
 DISULFID 59 90 Potential.
 DISULFID 69 80 Potential.  

Keyword

 Complete proteome; Disulfide bond; Electron transport; Lipoprotein; Membrane; Mitochondrion; Mitochondrion inner membrane; Myristate; Polymorphism; Reference proteome; Respiratory chain; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 137 AA 

Protein Sequence

Gene Ontology

 GO:0005758; C:mitochondrial intermembrane space; IDA:UniProtKB.
 GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
 GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; NAS:UniProtKB.
 GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; NAS:UniProtKB.
 GO:0044281; P:small molecule metabolic process; TAS:Reactome. 

Interpro

 IPR008698; NADH_UbQ_OxRdtase_B18_su. 

Pfam

 PF05676; NDUF_B7 

SMART

  

PROSITE

  

PRINTS