UniProt Accession

 H3_NEUCR; P07041; Q7RV46; Q8WZD9 

Genbank Protein ID

 X01612; AY062173; AL670543; AABX02000005 

Genbank Nucleotide ID

 CAA25761.1; AAL38973.1; CAD21510.1; EAA26767.1 

Protein Name

 Histone H3 

Protein Synonyms/Alias

  

Gene Name

 hh3 

Gene Synonyms/Alias

 B7K22.030; NCU01635 

Created Date

 July 27, 2013 

Organism

 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DS 

NCBI Taxa ID

 367110 

Lysine Modification

Position	Peptide	Type	References
10	RTKQTARKSTGGKAP	acetylation	[1]
15	ARKSTGGKAPRKQLA	acetylation	[1, 2]
19	TGGKAPRKQLASKAA	acetylation	[1]
24	PRKQLASKAARKSAP	acetylation	[1]
28	LASKAARKSAPSTGG	acetylation	[1]
57	REIRRYQKSTELLIR	acetylation	[1]

Reference

 [1] Mapping of lysine methylation and acetylation in core histones of Neurospora crassa.
 Xiong L, Adhvaryu KK, Selker EU, Wang Y.
 Biochemistry. 2010 Jun 29;49(25):5236-43. [PMID: 20433192]
 [2] The Neurospora crassa White Collar-1 dependent blue light response requires acetylation of histone H3 lysine 14 by NGF-1.
 Grimaldi B, Coiro P, Filetici P, Berge E, Dobosy JR, Freitag M, Selker EU, Ballario P.
 Mol Biol Cell. 2006 Oct;17(10):4576-83. [PMID: 16914525] 

Functional Description

 Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. 

Sequence Annotation

 MOD_RES 5 5 N6,N6,N6-trimethyllysine; alternate (By
 MOD_RES 5 5 N6,N6-dimethyllysine; alternate (By
 MOD_RES 5 5 N6-methyllysine; alternate (By
 MOD_RES 10 10 N6,N6,N6-trimethyllysine; alternate.
 MOD_RES 10 10 N6-acetyllysine; alternate (By
 MOD_RES 11 11 Phosphoserine (By similarity).
 MOD_RES 15 15 N6,N6-dimethyllysine; alternate (By
 MOD_RES 15 15 N6-acetyllysine; alternate (By
 MOD_RES 15 15 N6-methyllysine; alternate (By
 MOD_RES 19 19 N6-acetyllysine; alternate (By
 MOD_RES 19 19 N6-methyllysine; alternate (By
 MOD_RES 24 24 N6-acetyllysine; alternate (By
 MOD_RES 24 24 N6-methyllysine; alternate (By
 MOD_RES 28 28 N6,N6,N6-trimethyllysine; alternate (By
 MOD_RES 28 28 N6,N6-dimethyllysine; alternate (By
 MOD_RES 28 28 N6-acetyllysine; alternate (By
 MOD_RES 28 28 N6-methyllysine; alternate (By
 MOD_RES 37 37 N6,N6,N6-trimethyllysine; alternate (By
 MOD_RES 37 37 N6,N6-dimethyllysine; alternate (By
 MOD_RES 37 37 N6-acetyllysine; alternate (By
 MOD_RES 37 37 N6-methyllysine; alternate (By
 MOD_RES 57 57 N6-acetyllysine (By similarity).
 MOD_RES 65 65 N6-acetyllysine (By similarity).
 MOD_RES 80 80 N6,N6,N6-trimethyllysine; alternate (By
 MOD_RES 80 80 N6,N6-dimethyllysine; alternate (By
 MOD_RES 80 80 N6-methyllysine; alternate (By  

Keyword

 Acetylation; Chromosome; Complete proteome; DNA damage; DNA repair; DNA-binding; Methylation; Nucleosome core; Nucleus; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 136 AA 

Protein Sequence

Gene Ontology

 GO:0000786; C:nucleosome; IEA:UniProtKB-KW.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
 GO:0006334; P:nucleosome assembly; IEA:InterPro. 

Interpro

 IPR009072; Histone-fold.
 IPR007125; Histone_core_D.
 IPR000164; Histone_H3. 

Pfam

 PF00125; Histone 

SMART

 SM00428; H3 

PROSITE

 PS00322; HISTONE_H3_1
 PS00959; HISTONE_H3_2 

PRINTS

 PR00622; HISTONEH3.