CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021558
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Fukutin-related protein 
Protein Synonyms/Alias
  
Gene Name
 FKRP 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
396ERGFVWEKAVEGDFFubiquitination[1, 2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Could be a transferase involved in the modification of glycan moieties of alpha-dystroglycan (DAG1). 
Sequence Annotation
 CARBOHYD 172 172 N-linked (GlcNAc...).
 CARBOHYD 209 209 N-linked (GlcNAc...).
 DISULFID 6 6 Interchain.  
Keyword
 Cardiomyopathy; Cell membrane; Complete proteome; Congenital muscular dystrophy; Disease mutation; Disulfide bond; Endoplasmic reticulum; Glycoprotein; Golgi apparatus; Limb-girdle muscular dystrophy; Lissencephaly; Membrane; Reference proteome; Secreted; Signal-anchor; Transferase; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 495 AA 
Protein Sequence
MRLTRCQAAL AAAITLNLLV LFYVSWLQHQ PRNSRARGPR RASAAGPRVT VLVREFEAFD 60
NAVPELVDSF LQQDPAQPVV VAADTLPYPP LALPRIPNVR LALLQPALDR PAAASRPETY 120
VATEFVALVP DGARAEAPGL LERMVEALRA GSARLVAAPV ATANPARCLA LNVSLREWTA 180
RYGAAPAAPR CDALDGDAVV LLRARDLFNL SAPLARPVGT SLFLQTALRG WAVQLLDLTF 240
AAARQPPLAT AHARWKAERE GRARRAALLR ALGIRLVSWE GGRLEWFGCN KETTRCFGTV 300
VGDTPAYLYE ERWTPPCCLR ALRETARYVV GVLEAAGVRY WLEGGSLLGA ARHGDIIPWD 360
YDVDLGIYLE DVGNCEQLRG AEAGSVVDER GFVWEKAVEG DFFRVQYSES NHLHVDLWPF 420
YPRNGVMTKD TWLDHRQDVE FPEHFLQPLV PLPFAGFVAQ APNNYRRFLE LKFGPGVIEN 480
PQYPNPALLS LTGSG 495 
Gene Ontology
 GO:0016010; C:dystrophin-associated glycoprotein complex; IEA:Compara.
 GO:0005615; C:extracellular space; IDA:UniProtKB.
 GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
 GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005791; C:rough endoplasmic reticulum; IDA:UniProtKB.
 GO:0042383; C:sarcolemma; IEA:UniProtKB-SubCell.
 GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
 GO:0009101; P:glycoprotein biosynthetic process; IEA:Compara.
 GO:0016485; P:protein processing; IEA:Compara. 
Interpro
 IPR007074; LicD. 
Pfam
 PF04991; LicD 
SMART
  
PROSITE
  
PRINTS