UniProt Accession

 BASR_ECOLI; P30843; Q2M6J1; Q5MNC7; Q5MNC9; Q5MNE0; Q5MNE5; Q5MNF2; Q5MNH0 

Genbank Protein ID

 D14055; AY725270; AY725271; AY725272; AY725273; AY725274; AY725275; AY725276; AY725277; AY725278; AY725279; AY725280; AY725281; AY725282; AY725283; AY725284; AY725285; AY725286; AY725287; AY725288; AY725289; AY725290; AY725291; AY725292; AY725293; AY725294; AY725295; AY725296; AY725297; AY725298; AY725299; AY725300; AY725301; AY725302; AY725303; AY725304; AY725305; AY725306; AY725307; AY725308; AY725309; AY725310; AY725311; AY725312; AY725313; AY725314; AY725315; AY725316; AY725317; AY725318; AY725319; AY725320; AY725321; AY725322; AY725323; AY725324; AY725325; AY725326; AY725327; AY725328; AY725329; AY725330; AY725331; AY725332; AY725333; U14003; U00096; AP009048 

Genbank Nucleotide ID

 BAA03143.1; AAV92717.1; AAV92718.1; AAV92719.1; AAV92720.1; AAV92721.1; AAV92722.1; AAV92723.1; AAV92724.1; AAV92725.1; AAV92726.1; AAV92727.1; AAV92728.1; AAV92729.1; AAV92730.1; AAV92731.1; AAV92732.1; AAV92733.1; AAV92734.1; AAV92735.1; AAV92736.1; AAV92737.1; AAV92738.1; AAV92739.1; AAV92740.1; AAV92741.1; AAV92742.1; AAV92743.1; AAV92744.1; AAV92745.1; AAV92746.1; AAV92747.1; AAV92748.1; AAV92749.1; AAV92750.1; AAV92751.1; AAV92752.1; AAV92753.1; AAV92754.1; AAV92755.1; AAV92756.1; AAV92757.1; AAV92758.1; AAV92759.1; AAV92760.1; AAV92761.1; AAV92762.1; AAV92763.1; AAV92764.1; AAV92765.1; AAV92766.1; AAV92767.1; AAV92768.1; AAV92769.1; AAV92770.1; AAV92771.1; AAV92772.1; AAV92773.1; AAV92774.1; AAV92775.1; AAV92776.1; AAV92777.1; AAV92778.1; AAV92779.1; AAV92780.1; AAA97012.1; AAC77074.1; BAE78115.1 

Protein Name

 Transcriptional regulatory protein BasR 

Protein Synonyms/Alias

  

Gene Name

 basR 

Gene Synonyms/Alias

 pmrA; b4113; JW4074 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
70	LARIRQKKYTLPVLI	pupylation	[1]
87	ARDTLTDKIAGLDVG	acetylation	[2]
101	GADDYLVKPFALEEL	acetylation	[2]
153	EELILTPKEYALLSR	acetylation	[2]
164	LLSRLMLKAGSPVHR	acetylation	[2]
164	LLSRLMLKAGSPVHR	pupylation	[1]

Reference

 [1] Reconstitution of the Mycobacterium tuberculosis pupylation pathway in Escherichia coli.
 Cerda-Maira FA, McAllister F, Bode NJ, Burns KE, Gygi SP, Darwin KH.
 EMBO Rep. 2011 Jul 8;12(8):863-70. [PMID: 21738222]
 [2] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 Member of the two-component regulatory system BasS/BasR. BasR induces the transcription of the ugd, ais, arnBCADTEF and eptA-basRS loci, all involved in resistance to polymyxin (By similarity). 

Sequence Annotation

 DOMAIN 1 116 Response regulatory.
 MOD_RES 51 51 4-aspartylphosphate (By similarity).  

Keyword

 Activator; Antibiotic resistance; Complete proteome; Cytoplasm; DNA-binding; Phosphoprotein; Reference proteome; Transcription; Transcription regulation; Two-component regulatory system. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 222 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0000156; F:phosphorelay response regulator activity; IDA:EcoCyc.
 GO:0006355; P:regulation of transcription, DNA-dependent; IMP:EcoCyc.
 GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
 GO:0010041; P:response to iron(III) ion; IMP:EcoCyc.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR011006; CheY-like_superfamily.
 IPR001867; Sig_transdc_resp-reg_C.
 IPR001789; Sig_transdc_resp-reg_receiver.
 IPR011991; WHTH_DNA-bd_dom. 

Pfam

 PF00072; Response_reg
 PF00486; Trans_reg_C 

SMART

 SM00448; REC
 SM00862; Trans_reg_C 

PROSITE

 PS50110; RESPONSE_REGULATORY 

PRINTS