UniProt Accession

 PRIO_CRIGR; Q60506 

Genbank Protein ID

 M33958 

Genbank Nucleotide ID

 AAA37013.1 

Protein Name

 Major prion protein 

Protein Synonyms/Alias

 PrP; PrP27-30; PrP33-35C; CD230 

Gene Name

 PRNP 

Gene Synonyms/Alias

 PRP 

Created Date

 July 27, 2013 

Organism

 Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) 

NCBI Taxa ID

 10029 

Lysine Modification

Position	Peptide	Type	References
101	GTHNQWNKPSKPKTN	acetylation	[1]
104	NQWNKPSKPKTNMKH	acetylation	[1]
106	WNKPSKPKTNMKHVA	acetylation	[1]
220	MCVTQYQKESQAYYD	acetylation	[1]

Reference

 [1] Probing structural differences between PrP(C) and PrP(Sc) by surface nitration and acetylation: evidence of conformational change in the C-terminus.
 Gong B, Ramos A, Vázquez-Fernández E, Silva CJ, Alonso J, Liu Z, Requena JR.
 Biochemistry. 2011 Jun 7;50(22):4963-72. [PMID: 21526750] 

Functional Description

 May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity). 

Sequence Annotation

 REPEAT 51 59 1.
 REPEAT 60 67 2.
 REPEAT 68 75 3.
 REPEAT 76 83 4.
 REPEAT 84 91 5.
 REGION 23 231 Interaction with GRB2, ERI3 and SYN1 (By
 REGION 51 91 5 X 8 AA tandem repeats of P-H-G-G-G-W-G-
 REGION 90 231 PrP27-30 (protease resistant core).
 METAL 61 61 Copper or zinc 1 (By similarity).
 METAL 62 62 Copper or zinc 1; via amide nitrogen (By
 METAL 63 63 Copper or zinc 1; via amide nitrogen and
 METAL 69 69 Copper or zinc 2 (By similarity).
 METAL 70 70 Copper or zinc 2; via amide nitrogen (By
 METAL 71 71 Copper or zinc 2; via amide nitrogen and
 METAL 77 77 Copper or zinc 3 (By similarity).
 METAL 78 78 Copper or zinc 3; via amide nitrogen (By
 METAL 79 79 Copper or zinc 3; via amide nitrogen and
 METAL 85 85 Copper or zinc 4 (By similarity).
 METAL 86 86 Copper or zinc 4; via amide nitrogen (By
 METAL 87 87 Copper or zinc 4; via amide nitrogen and
 LIPID 231 231 GPI-anchor amidated serine (Potential).
 CARBOHYD 181 181 N-linked (GlcNAc...) (By similarity).
 CARBOHYD 197 197 N-linked (GlcNAc...) (By similarity).
 DISULFID 179 214 By similarity.  

Keyword

 Amyloid; Cell membrane; Copper; Disulfide bond; Glycoprotein; Golgi apparatus; GPI-anchor; Lipoprotein; Membrane; Metal-binding; Prion; Repeat; Signal; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 254 AA 

Protein Sequence

Gene Ontology

 GO:0031225; C:anchored to membrane; IEA:UniProtKB-KW.
 GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0005507; F:copper ion binding; ISS:UniProtKB.
 GO:0051260; P:protein homooligomerization; IEA:InterPro. 

Interpro

 IPR000817; Prion.
 IPR022416; Prion/Doppel_prot_b-ribbon_dom.
 IPR025860; Prion_N_dom. 

Pfam

 PF00377; Prion
 PF11587; Prion_bPrPp 

SMART

 SM00157; PRP 

PROSITE

 PS00291; PRION_1
 PS00706; PRION_2 

PRINTS

 PR00341; PRION.