| Tag | Content |
|---|
| CPLM ID | CPLM-020944 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Signal recognition particle receptor subunit alpha |
Protein Synonyms/Alias | SR-alpha; Docking protein alpha; DP-alpha |
Gene Name | Srpr |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 329 | LKGLVGSKSLSREDM | ubiquitination | [1] | | 342 | DMESVLDKMRDHLIA | ubiquitination | [1] | | 490 | TMVQLFEKGYGKDAA | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Component of the SRP (signal recognition particle) receptor. Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system (By similarity). |
Sequence Annotation | NP_BIND 423 430 GTP (By similarity).
NP_BIND 518 522 GTP (By similarity).
NP_BIND 586 589 GTP (By similarity).
MOD_RES 295 295 Phosphoserine.
MOD_RES 296 296 Phosphoserine.
MOD_RES 297 297 Phosphoserine. |
Keyword | Complete proteome; Endoplasmic reticulum; GTP-binding; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 636 AA |
Protein Sequence | MLDFFTIFSK GGLVLWCFQG VSDSCTGPVN ALIRSVLLQE RGGNNSFTHE ALTLKYKLDN 60
QFELVFVVGF QKILTLTYVD KLIDDVHRLF RDKYRTEIQQ QSALSLLNGT FDFQNDFLRL 120
LREAEESSKI RAPTTMKKFE DSEKAKKPVR SMIETRGEKT KEKAKNNKKR GAKKEGSDGT 180
LATSKTAPAE KSGLSAGPEN GELSKEELIR RKREEFIQKH GKGLDKSSKS TKSDTPKEKG 240
KKAPRVWELG GCANKEVLDY STPTTNGTPE AALSEDINLI RGTGPGGQLQ DLDCSSSDDE 300
GATQNTKPSA TKGTLGGMFG MLKGLVGSKS LSREDMESVL DKMRDHLIAK NVAADIAVQL 360
CESVANKLEG KVMGTFSTVT STVKQALQES LVQILQPQRR VDMLRDIMDA QRRQRPYVVT 420
FCGVNGVGKS TNLAKISFWL LENGFSVLIA ACDTFRAGAV EQLRTHTRRL TALHPPEKHG 480
GRTMVQLFEK GYGKDAAGIA MEAIAFARNQ GFDVVLVDTA GRMQDNAPLM TALAKLITVN 540
TPDLVLFVGE ALVGNEAVDQ LVKFNRALAD HSMAQTPRLI DGIVLTKFDT IDDKVGAAIS 600
MTYITSKPIV FVGTGQTYCD LRSLNAKAVV AALMKA 636 |
Gene Ontology | GO:0005785; C:signal recognition particle receptor complex; IEA:InterPro. GO:0005525; F:GTP binding; IEA:UniProtKB-KW. GO:0003924; F:GTPase activity; IEA:InterPro. GO:0005047; F:signal recognition particle binding; IEA:InterPro. GO:0006614; P:SRP-dependent cotranslational protein targeting to membrane; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |