CPLM-023144

Genbank Nucleotide ID

Ras-related protein Rab-23

Protein Synonyms/Alias

Homo sapiens (Human)

Position	Peptide	Type	References
132	LLDDSCIKNEEAEAL	ubiquitination	[1]
163	LNVNEVFKYLAEKYL	ubiquitination	[2, 3]

[1] Global identification of modular cullin-RING ligase substrates.
Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
[2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
[3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
Chen Z, Zhou Y, Song J, Zhang Z.
Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]

Functional Description

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Together with SUFU, prevents nuclear import of GLI1, and thereby inhibits GLI1 transcription factor activity. Regulates GLI1 in differentiating chondrocytes. Likewise, regulates GLI3 proteolytic processing and modulates GLI2 and GLI3 transcription factor activity. Plays a role in autophagic vacuole assembly, and mediates defense against pathogens, such as S.aureus, by promoting their capture by autophagosomes that then merge with lysosomes.

NP_BIND 16 23 GTP (By similarity).
NP_BIND 64 68 GTP (By similarity).
NP_BIND 121 124 GTP (By similarity).
MOTIF 38 46 Effector region (By similarity).
MOD_RES 234 234 Cysteine methyl ester (Potential).
LIPID 234 234 S-geranylgeranyl cysteine (By

Cell membrane; Complete proteome; Craniosynostosis; Cytoplasm; Cytoplasmic vesicle; Developmental protein; Disease mutation; Endosome; GTP-binding; Lipoprotein; Membrane; Methylation; Nucleotide-binding; Polymorphism; Prenylation; Protein transport; Reference proteome; Transport.

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

GO:0005776; C:autophagic vacuole; IDA:UniProtKB.
GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
GO:0045335; C:phagocytic vesicle; IDA:UniProtKB.
GO:0030670; C:phagocytic vesicle membrane; IEA:UniProtKB-SubCell.
GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
GO:0003924; F:GTPase activity; IDA:UniProtKB.
GO:0000045; P:autophagic vacuole assembly; IMP:UniProtKB.
GO:0006968; P:cellular defense response; IMP:UniProtKB.
GO:0097094; P:craniofacial suture morphogenesis; IMP:UniProtKB.
GO:0042733; P:embryonic digit morphogenesis; IEA:Compara.
GO:0045861; P:negative regulation of proteolysis; IEA:Compara.
GO:0042992; P:negative regulation of transcription factor import into nucleus; IMP:UniProtKB.
GO:0015031; P:protein transport; IEA:UniProtKB-KW.
GO:0008589; P:regulation of smoothened signaling pathway; IEA:Compara.
GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
GO:0021513; P:spinal cord dorsal/ventral patterning; IEA:Compara.

IPR027417; P-loop_NTPase.
IPR005225; Small_GTP-bd_dom.
IPR001806; Small_GTPase.
IPR003579; Small_GTPase_Rab_type.

PR00449; RASTRNSFRMNG.