| Tag | Content |
|---|
| CPLM ID | CPLM-008059 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Ribonucleoside-diphosphate reductase large subunit |
Protein Synonyms/Alias | Ribonucleoside-diphosphate reductase subunit M1; Ribonucleotide reductase large subunit |
Gene Name | RnrL |
Gene Synonyms/Alias | CG5371 |
Created Date | July 27, 2013 |
Organism | Drosophila melanogaster (Fruit fly) |
NCBI Taxa ID | 7227 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 11 | NKSMKTSKLYVIKRD | acetylation | [1] | | 28 | QEEVHFDKITSRIQK | acetylation | [1] |
|
Reference | [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation. Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C. Sci Signal. 2011 Jul 26;4(183):ra48. [ PMID: 21791702] |
Functional Description | Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. |
Sequence Annotation | DOMAIN 12 103 ATP-cone.
REGION 22 28 Allosteric activator binding (By
REGION 228 229 Substrate binding (By similarity).
REGION 296 299 Allosteric effector binding, determines
REGION 438 442 Substrate binding (By similarity).
REGION 614 618 Substrate binding (By similarity).
ACT_SITE 438 438 Proton acceptor (By similarity).
ACT_SITE 440 440 Cysteine radical intermediate (By
ACT_SITE 442 442 Proton acceptor (By similarity).
BINDING 16 16 Allosteric activator (By similarity).
BINDING 64 64 Allosteric activator (By similarity).
BINDING 99 99 Allosteric activator (By similarity).
BINDING 213 213 Substrate (By similarity).
BINDING 258 258 Substrate; via amide nitrogen (By
MOD_RES 778 778 Phosphothreonine.
MOD_RES 782 782 Phosphoserine.
MOD_RES 786 786 Phosphotyrosine.
DISULFID 229 455 Redox-active (By similarity). |
Keyword | Allosteric enzyme; ATP-binding; Complete proteome; Disulfide bond; DNA replication; Nucleotide-binding; Oxidoreductase; Phosphoprotein; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 812 AA |
Protein Sequence | MLKNKSMKTS KLYVIKRDGR QEEVHFDKIT SRIQKLCYNL NMDFVDPVTI TLQVINGLYC 60
GVTTQELDNL AAEIAAGLTC NHPDYAILAA RIAVSNLHKE TKKAFSDVFE DLYNHVNKET 120
NQKVPLVSEF HYNVVKKNAT RLNSSIIYDR DFGYNYFGFK TLERSYLLKR NGKIAERPQH 180
MLMRVAIGIH GEDIDAAVET YNLLSERYFT HASPTLFAAA TNRPQLSSCF LLTMTADSIE 240
GIFKSVEQCA MISKSAGGIG LNVHCIRAKG TSICGTNGTS NGLVPMLRVF NNVARYVDQG 300
GGKRPGAFAI YLEPWHSDVF EFLELKKNTG KEENRARDLF YALWIPDLFM KRVEANGDWS 360
LMCPHKCPGL HDVWGDEFEK LYEKYEQEGR ANRTVKAQSL WFAIIEAQVE TGNPYMLFKD 420
ACNRKSNQQN VGTIKCSNLC TEIVEYSAPD EIAVCNLASI ALNMFVTPEK TYDFKKLKEV 480
TKIVTKNLNK IIDINYYPLP EARKSNLRHR PVGIGIQGFA DALILMRFPY ESEEAGLLNQ 540
QIFETIYYGA LEASCELAQT EGPYETYEGS PVSKGILQYD MWDKVPTNLW DWQKLKESIR 600
MHGVRNSLLV APMPTASTAQ IMGNNESFEP YTTNIYTRRV LSGEFQVVNH HLLRDLTELD 660
LWDDDMKNQI ISSRGSIQNI ETIPPKVRDL YKTVWEISVK STIKMAADRG AFIDQSQSFN 720
IHVAEPNYGK LTSIHFYSWK AGLKTGMYYL RTKPAANAIQ FTVNKKQGAV SMNGQNGTAE 780
GSPQKYEEDR ERKMADMVCS LENKDACMSC GS 812 |
Gene Ontology | GO:0005971; C:ribonucleoside-diphosphate reductase complex; IEA:InterPro. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0004748; F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor; ISS:UniProtKB. GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; IMP:FlyBase. GO:0009263; P:deoxyribonucleotide biosynthetic process; ISS:UniProtKB. GO:0006260; P:DNA replication; IEA:UniProtKB-UniPathway. GO:0042246; P:tissue regeneration; IMP:FlyBase. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |