CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018262
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 RelA-associated inhibitor 
Protein Synonyms/Alias
 Inhibitor of ASPP protein; Protein iASPP; NFkB-interacting protein 1; PPP1R13B-like protein 
Gene Name
 PPP1R13L 
Gene Synonyms/Alias
 IASPP; NKIP1; PPP1R13BL; RAI 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
541ALPPTHKKQYQQIISubiquitination[1, 2]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
 Regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1. Also inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis. 
Sequence Annotation
 REPEAT 659 691 ANK 1.
 REPEAT 692 724 ANK 2.
 DOMAIN 758 820 SH3.
 MOD_RES 102 102 Phosphoserine.
 MOD_RES 110 110 Phosphoserine.
 MOD_RES 113 113 Phosphoserine.
 MOD_RES 119 119 Phosphoserine.
 MOD_RES 120 120 Phosphoserine.
 MOD_RES 123 123 Phosphothreonine.
 MOD_RES 134 134 Phosphoserine.
 MOD_RES 183 183 Phosphoserine.
 MOD_RES 187 187 Phosphoserine.
 MOD_RES 203 203 Phosphoserine.
 MOD_RES 280 280 Phosphoserine.
 MOD_RES 308 308 Phosphothreonine (By similarity).
 MOD_RES 316 316 Phosphoserine.
 MOD_RES 332 332 Phosphoserine.
 MOD_RES 526 526 Phosphoserine.
 MOD_RES 567 567 Phosphoserine.
 MOD_RES 597 597 Phosphoserine.  
Keyword
 3D-structure; ANK repeat; Apoptosis; Complete proteome; Cytoplasm; Nucleus; Phosphoprotein; Reference proteome; Repeat; Repressor; SH3 domain; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 828 AA 
Protein Sequence
MDSEAFQSAR DFLDMNFQSL AMKHMDLKQM ELDTAAAKVD ELTKQLESLW SDSPAPPGPQ 60
AGPPSRPPRY SSSSIPEPFG SRGSPRKAAT DGADTPFGRS ESAPTLHPYS PLSPKGRPSS 120
PRTPLYLQPD AYGSLDRATS PRPRAFDGAG SSLGRAPSPR PGPGPLRQQG PPTPFDFLGR 180
AGSPRGSPLA EGPQAFFPER GPSPRPPATA YDAPASAFGS SLLGSGGSAF APPLRAQDDL 240
TLRRRPPKAW NESDLDVAYE KKPSQTASYE RLDVFARPAS PSLQLLPWRE SSLDGLGGTG 300
KDNLTSATLP RNYKVSPLAS DRRSDAGSYR RSLGSAGPSG TLPRSWQPVS RIPMPPSSPQ 360
PRGAPRQRPI PLSMIFKLQN AFWEHGASRA MLPGSPLFTR APPPKLQPQP QPQPQPQSQP 420
QPQLPPQPQT QPQTPTPAPQ HPQQTWPPVN EGPPKPPTEL EPEPEIEGLL TPVLEAGDVD 480
EGPVARPLSP TRLQPALPPE AQSVPELEEV ARVLAEIPRP LKRRGSMEQA PAVALPPTHK 540
KQYQQIISRL FHRHGGPGPG GPEPELSPIT EGSEARAGPP APAPPAPIPP PAPSQSSPPE 600
QPQSMEMRSV LRKAGSPRKA RRARLNPLVL LLDAALTGEL EVVQQAVKEM NDPSQPNEEG 660
ITALHNAICG ANYSIVDFLI TAGANVNSPD SHGWTPLHCA ASCNDTVICM ALVQHGAAIF 720
ATTLSDGATA FEKCDPYREG YADCATYLAD VEQSMGLMNS GAVYALWDYS AEFGDELSFR 780
EGESVTVLRR DGPEETDWWW AALHGQEGYV PRNYFGLFPR VKPQRSKV 828 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; TAS:ProtInc.
 GO:0003714; F:transcription corepressor activity; TAS:ProtInc.
 GO:0008134; F:transcription factor binding; TAS:ProtInc.
 GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
 GO:0060048; P:cardiac muscle contraction; IEA:Compara.
 GO:0003215; P:cardiac right ventricle morphogenesis; IEA:Compara.
 GO:0031076; P:embryonic camera-type eye development; IEA:Compara.
 GO:0042633; P:hair cycle; IEA:Compara.
 GO:0035264; P:multicellular organism growth; IEA:Compara.
 GO:0048871; P:multicellular organismal homeostasis; IEA:Compara.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0009791; P:post-embryonic development; IEA:Compara.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0003229; P:ventricular cardiac muscle tissue development; IEA:Compara. 
Interpro
 IPR002110; Ankyrin_rpt.
 IPR020683; Ankyrin_rpt-contain_dom.
 IPR001452; SH3_domain. 
Pfam
 PF12796; Ank_2
 PF00018; SH3_1 
SMART
 SM00248; ANK
 SM00326; SH3 
PROSITE
 PS50297; ANK_REP_REGION
 PS50088; ANK_REPEAT
 PS50002; SH3 
PRINTS
 PR00452; SH3DOMAIN.