CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-029818
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Lymphoid-specific helicase 
Protein Synonyms/Alias
  
Gene Name
 HELLS 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
58RLQHLLEKSNIYSKFubiquitination[1, 2, 3, 4]
64EKSNIYSKFLLTKMEubiquitination[1]
69YSKFLLTKMEQQQLEubiquitination[3]
106SIDASEEKPVMRKKRacetylation[4]
106SIDASEEKPVMRKKRubiquitination[4]
139LSVAKKNKKENEDENubiquitination[3]
161VEDLQKNKDSNSIIKubiquitination[3, 4]
180ETVRQNTKFFFDPVRubiquitination[3]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
 Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI.
 J Proteome Res. 2012 Feb 3;11(2):796-807. [PMID: 22053931]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 192 AA 
Protein Sequence
MVEQLDTAVI TPAMLEEEEQ LEAAGLERER KMLEKARMSW DRESTEIRYR RLQHLLEKSN 60
IYSKFLLTKM EQQQLEEQKK KEKLERKKES LKVKKGKNSI DASEEKPVMR KKRGREDESY 120
NISEVMSKEE ILSVAKKNKK ENEDENSSST NLCVEDLQKN KDSNSIIKDR LSETVRQNTK 180
FFFDPVRKCN GQ 192 
Gene Ontology
 GO:0005721; C:centromeric heterochromatin; IEA:Compara.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0003682; F:chromatin binding; IEA:Compara.
 GO:0031508; P:centromeric heterochromatin assembly; IEA:Compara.
 GO:0046651; P:lymphocyte proliferation; IEA:Compara.
 GO:0010216; P:maintenance of DNA methylation; IEA:Compara.
 GO:0006346; P:methylation-dependent chromatin silencing; IEA:Compara.
 GO:0043066; P:negative regulation of apoptotic process; IEA:Compara.
 GO:0001655; P:urogenital system development; IEA:Compara. 
Interpro
  
Pfam
  
SMART
  
PROSITE
  
PRINTS