UniProt Accession

 DYL1_MOUSE; P63168; Q15701; Q3UGE7 

Genbank Protein ID

 AF020185; AK002522; AK010614; AK010685; AK013721; AK082923; AK147977; BC008106; BC034258 

Genbank Nucleotide ID

 AAD01643.1; BAB22160.1; BAB27063.1; BAB27117.1; BAB28970.1; BAC38691.1; BAE28262.1; AAH08106.1; AAH34258.1 

Protein Name

 Dynein light chain 1, cytoplasmic 

Protein Synonyms/Alias

 8 kDa dynein light chain; DLC8; Dynein light chain LC8-type 1; Protein inhibitor of neuronal nitric oxide synthase; PIN; mPIN 

Gene Name

 Dynll1 

Gene Synonyms/Alias

 Dlc1; Dncl1; Dnclc1 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
36	LEKYNIEKDIAAHIK	acetylation	[1, 2, 3]
36	LEKYNIEKDIAAHIK	ubiquitination	[4]
49	IKKEFDKKYNPTWHC	acetylation	[1]
49	IKKEFDKKYNPTWHC	ubiquitination	[4]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [4] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures (By similarity). 

Sequence Annotation

 REGION 67 89 Interaction with ESR1 (By similarity).
 MOD_RES 36 36 N6-acetyllysine (By similarity).
 MOD_RES 88 88 Phosphoserine (By similarity).  

Keyword

 Acetylation; Activator; Apoptosis; Complete proteome; Cytoplasm; Cytoskeleton; Dynein; Microtubule; Mitochondrion; Motor protein; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 89 AA 

Protein Sequence

Gene Ontology

 GO:0005813; C:centrosome; IEA:Compara.
 GO:0005868; C:cytoplasmic dynein complex; ISS:UniProtKB.
 GO:0005829; C:cytosol; IDA:MGI.
 GO:0000776; C:kinetochore; ISS:UniProtKB.
 GO:0016020; C:membrane; IDA:MGI.
 GO:0005874; C:microtubule; IEA:UniProtKB-KW.
 GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
 GO:0072686; C:mitotic spindle; ISS:UniProtKB.
 GO:0008180; C:signalosome; IEA:Compara.
 GO:0003774; F:motor activity; IEA:UniProtKB-KW.
 GO:0030235; F:nitric-oxide synthase regulator activity; IEA:Compara.
 GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
 GO:0007018; P:microtubule-based movement; TAS:MGI.
 GO:0042326; P:negative regulation of phosphorylation; IEA:Compara.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006810; P:transport; IEA:UniProtKB-KW. 

Interpro

 IPR019763; Dynein_light_1/2_CS.
 IPR001372; Dynein_light_chain_typ-1/2. 

Pfam

 PF01221; Dynein_light 

SMART

  

PROSITE

 PS01239; DYNEIN_LIGHT_1 

PRINTS