CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004327
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Embryonic polarity protein dorsal 
Protein Synonyms/Alias
  
Gene Name
 dl 
Gene Synonyms/Alias
 CG6667 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
382TQNIPPIKTEPRDTSsumoylation[1]
Reference
 [1] Conjugation of Smt3 to dorsal may potentiate the Drosophila immune response.
 Bhaskar V, Smith M, Courey AJ.
 Mol Cell Biol. 2002 Jan;22(2):492-504. [PMID: 11756545] 
Functional Description
 Embryonic developmental protein. The lateral or ventral identity of a cell depends upon the concentration of dorsal protein in its nucleus during the blastoderm stage. Dorsal is a morphogenetic protein that specifically binds to the kappa B- related consensus sequence 5'-GRGAAAANCC-3', located in the enhancer region of zygotic genes such as Zen, Twist, Snail and Decapentaplegic. Mediates an immune response in Drosophila larvae. 
Sequence Annotation
 DOMAIN 47 342 RHD.
 MOTIF 756 773 Nuclear localization signal (Potential).
 MOD_RES 312 312 Phosphoserine; by PKA (Potential).  
Keyword
 Activator; Alternative splicing; Complete proteome; Cytoplasm; Developmental protein; DNA-binding; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 999 AA 
Protein Sequence
MFPNQNNGAA PGQGPAVDGQ QSLNYNGLPA QQQQQLAQST KNVRKKPYVK ITEQPAGKAL 60
RFRYECEGRS AGSIPGVNST PENKTYPTIE IVGYKGRAVV VVSCVTKDTP YRPHPHNLVG 120
KEGCKKGVCT LEINSETMRA VFSNLGIQCV KKKDIEAALK AREEIRVDPF KTGFSHRFQP 180
SSIDLNSVRL CFQVFMESEQ KGRFTSPLPP VVSEPIFDKK AMSDLVICRL CSCSATVFGN 240
TQIILLCEKV AKEDISVRFF EEKNGQSVWE AFGDFQHTDV HKQTAITFKT PRYHTLDITE 300
PAKVFIQLRR PSDGVTSEAL PFEYVPMDSD PAHLRRKRQK TGGDPMHLLL QQQQKQQLQN 360
DHQDGRQTNM NCWNTQNIPP IKTEPRDTSP QPFGLSYRAP PELTPSPQPL SPSSNYNHNS 420
TPSPYNMASA VTPTNGQQQL MSPNHPQQQQ QQQQYGATDL GSNYNPFAQQ VLAQQQQHQQ 480
QQQQHQHQHQ QQHQQQQQQQ QQQQQQSLQF HANPFGNPGG NSWESKFSAA AVAAAAATAT 540
GAAPANGNSN NLSNLNNPFT MHNLLTSGGG PGNANNLQWN LTTNHLHNQH TLHQQQQLQQ 600
QQQQQYDNTA PTNNNANLNN NNNNNNTAGN QADNNGPTLS NLLSFDSGQL VHINSEDQQI 660
LRLNSEDLQI SNLSIST 677 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:FlyBase.
 GO:0031594; C:neuromuscular junction; IDA:FlyBase.
 GO:0005634; C:nucleus; IDA:FlyBase.
 GO:0001077; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; IDA:FlyBase.
 GO:0000977; F:RNA polymerase II regulatory region sequence-specific DNA binding; IDA:FlyBase.
 GO:0009952; P:anterior/posterior pattern specification; TAS:FlyBase.
 GO:0009950; P:dorsal/ventral axis specification; TAS:FlyBase.
 GO:0001715; P:ectodermal cell fate specification; TAS:FlyBase.
 GO:0010004; P:gastrulation involving germ band extension; TAS:FlyBase.
 GO:0008354; P:germ cell migration; TAS:FlyBase.
 GO:0007507; P:heart development; NAS:FlyBase.
 GO:0035006; P:melanization defense response; IMP:FlyBase.
 GO:0007501; P:mesodermal cell fate specification; TAS:FlyBase.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; TAS:FlyBase.
 GO:0048935; P:peripheral nervous system neuron development; IMP:FlyBase.
 GO:0042387; P:plasmatocyte differentiation; IMP:FlyBase.
 GO:0000381; P:regulation of alternative mRNA splicing, via spliceosome; IMP:FlyBase.
 GO:0035206; P:regulation of hemocyte proliferation; IDA:FlyBase.
 GO:0008063; P:Toll signaling pathway; TAS:FlyBase.
 GO:0007419; P:ventral cord development; NAS:FlyBase. 
Interpro
 IPR013783; Ig-like_fold.
 IPR014756; Ig_E-set.
 IPR002909; IPT_TIG_rcpt.
 IPR000451; NF_Rel_Dor.
 IPR008967; p53-like_TF_DNA-bd.
 IPR011539; RHD. 
Pfam
 PF00554; RHD 
SMART
 SM00429; IPT 
PROSITE
 PS01204; REL_1
 PS50254; REL_2 
PRINTS
 PR00057; NFKBTNSCPFCT.