CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-012145
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Dynactin subunit 2 
Protein Synonyms/Alias
 50 kDa dynein-associated polypeptide; Dynactin complex 50 kDa subunit; DCTN-50; p50 dynamitin 
Gene Name
 DCTN2 
Gene Synonyms/Alias
 DCTN50 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
145LTPVLLAKQLAALKQubiquitination[1]
151AKQLAALKQQLVASHubiquitination[1]
180DPDGALAKRLLLQLEubiquitination[2]
Reference
 [1] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
 Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development. 
Sequence Annotation
 MOD_RES 2 2 N-acetylalanine.
 MOD_RES 6 6 Phosphotyrosine.
 MOD_RES 83 83 Phosphoserine.
 MOD_RES 86 86 Phosphotyrosine (By similarity).  
Keyword
 Acetylation; Alternative splicing; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Dynein; Membrane; Microtubule; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 401 AA 
Protein Sequence
MADPKYADLP GIARNEPDVY ETSDLPEDDQ AEFDAFAQEL EELTSTSVEH IIVNPNAAYD 60
KFKDKRVGTK GLDFSDRIGK TKRTGYESGE YEMLGEGLGV KETPQQKYQR LLHEVQELTT 120
EVEKIKTTVK ESATEEKLTP VLLAKQLAAL KQQLVASHLE KLLGPDAAIN LTDPDGALAK 180
RLLLQLEATK NSKGGSGGKT TGTPPDSSLV TYELHSRPEQ DKFSQAAKVA ELEKRLTELE 240
TAVRCDQDAQ NPLSAGLQGA CLMETVELLQ AKVSALDLAV LDQVEARLQS VLGKVNEIAK 300
HKASVEDADT QSKVHQLYET IQRWSPIAST LPELVQRLVT IKQLHEQAMQ FGQLLTHLDT 360
TQQMIANSLK DNTTLLTQVQ TTMRENLATV EGNFASIDER MKKLGK 406 
Gene Ontology
 GO:0005813; C:centrosome; IDA:UniProtKB.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005869; C:dynactin complex; IDA:UniProtKB.
 GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
 GO:0030426; C:growth cone; IEA:Compara.
 GO:0000776; C:kinetochore; IDA:UniProtKB.
 GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
 GO:0005874; C:microtubule; IEA:UniProtKB-KW.
 GO:0031982; C:vesicle; IDA:UniProtKB.
 GO:0003774; F:motor activity; IEA:UniProtKB-KW.
 GO:0019886; P:antigen processing and presentation of exogenous peptide antigen via MHC class II; TAS:Reactome.
 GO:0008283; P:cell proliferation; IMP:UniProtKB.
 GO:0000086; P:G2/M transition of mitotic cell cycle; TAS:Reactome.
 GO:0007067; P:mitosis; IMP:UniProtKB.
 GO:0007052; P:mitotic spindle organization; IEA:Compara. 
Interpro
 IPR006996; Dynamitin_2su. 
Pfam
  
SMART
  
PROSITE
  
PRINTS