CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-041504
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein Mcm4 
Protein Synonyms/Alias
 RCG36531, isoform CRA_b 
Gene Name
 Mcm4 
Gene Synonyms/Alias
 rCG_36531 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
219EHIKSFGKNLYRQLIacetylation[1]
857DFLTVTGKTVRLL**acetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; DNA replication; DNA-binding; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 862 AA 
Protein Sequence
MSSPASTPSR RSSRRGRVTP TQSLRSEESR SSPSGRRRGE DSSTGELLPM PTSPGADLQS 60
PAAQNALFSS PPQMHSSAIP LEFDVSSPLT YGTPSSRVEG TPRSGVRGTP MRQRPDLGSA 120
RKGLQVDLQS DGAAAEDTVA SEQSLGQKLV IWGTDVNVAT CKEHFQRFLQ CFTDPLAKEE 180
ENVGIDITQP LYMQRLGEIN ITGEPFLNVN CEHIKSFGKN LYRQLISYPQ EVIPTFDMAV 240
NEIFFDRYPD SILEHQIQVR PFNALKTKSM RNLNPEDIDQ LITISGMVIR TSQLIPEMQE 300
AFFQCQVCAH TTRVEMDRGR IAEPCTCVHC HTTHSMALIH NRSLFSDKQM IKLQESPEDM 360
PAGQTPHTVV LFAHNDLVDK VQPGDRVNVT GIYRAVPIRV NPRVSNVKSV YKTHIDVIHY 420
RKTDAKRLHG LDEEAEQKLF SEKRVKLLKE LSRKPDIYER LASALAPSIY EHEDIKKGIL 480
LQLFGGTRKD FSHTGRGKFR AEINILLCGD PGTSKSQLLQ YVYNLVPRGQ YTSGKGSSAV 540
GLTAYVMKDP ETRQLVLQTG ALVLSDNGIC CIDEFDKMNE STRSVLHEVM EQQTLSIAKA 600
GIICQLNART SVLAAANPIE SQWNPKKTTI ENIQLPHTLL SRFDLIFLML DPQDEAYDRR 660
LAHHLVSLYY QSEEQVEQEF LDMAVLKDYI AYAHSTIMPR LSEEASQALI EAYVNMRKIG 720
SSRGMVSAYP RQLESLIRLA EAHAKVRFSD KVEAIDVEEA KRLHREALKQ SATDPRTGIV 780
DISILTTGMS ATSRKRKEEL AEALRKLILS KGKTPALKYQ QLFEDIRGQS DTAITKDMFE 840
EALRALADDD FLTVTGKTVR LL 862 
Gene Ontology
 GO:0042555; C:MCM complex; IEA:Compara.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004003; F:ATP-dependent DNA helicase activity; IEA:Compara.
 GO:0003697; F:single-stranded DNA binding; IEA:Compara.
 GO:0006270; P:DNA replication initiation; IEA:InterPro.
 GO:0006268; P:DNA unwinding involved in replication; IEA:Compara. 
Interpro
 IPR003593; AAA+_ATPase.
 IPR008047; MCM_4.
 IPR018525; MCM_CS.
 IPR001208; MCM_DNA-dep_ATPase.
 IPR012340; NA-bd_OB-fold.
 IPR027417; P-loop_NTPase.
 IPR004039; Rubredoxin-type_fold. 
Pfam
 PF00493; MCM 
SMART
 SM00382; AAA
 SM00350; MCM 
PROSITE
 PS00847; MCM_1
 PS50051; MCM_2 
PRINTS
 PR01657; MCMFAMILY.
 PR01660; MCMPROTEIN4.