CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-031570
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 RNA polymerase I-specific transcription initiation factor RRN3 
Protein Synonyms/Alias
 cDNA FLJ53965, highly similar to RNA polymerase I-specific transcription initiation factor RRN3 
Gene Name
 RRN3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
29TVTEVLLKYKKGETNubiquitination[1]
32EVLLKYKKGETNDFEubiquitination[2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Initiation factor; Protein biosynthesis; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 618 AA 
Protein Sequence
MRALENDFFN SPPRKTVRFG GTVTEVLLKY KKGETNDFEL LKNQLLDPDI KDDQIINWLL 60
EFRSSIMYLT KDFEQLISII LRLPWLNRSQ TVVEEYLAFL GNLVSAQTVF LRPCLSMIAS 120
HFVPPRVIIK EGDVDVSDSD DEDDNLPANF DTCHRALQII ARYVPSTPWF LMPILVEKFP 180
FVRKSERTLE CYVHNLLRIS VYFPTLRHEI LELIIEKLLK LDVNASRQGI EDAEETATQT 240
CGGTDSTEGL FNMDEDEETE HETKAGPERL DQMVHPVAER LDILMSLVLS YMKDVCYVDG 300
KVDNGKTKDL YRDLINIFDK LLLPTHASCH VQFFMFYLCS FKLGFAEAFL EHLWKKLQDP 360
SNPAIIRQAA GNYIGSFLAR AKFIPLITVK SCLDLLVNWL HIYLNNQDSG TKAFCDVALH 420
GPFYSACQAV FYTFVFRHKQ LLSGNLKEGL QYLQSLNFER IVMSQLNPLK ICLPSVVNFF 480
AAITNKYQLV FCYTIIERNN RQMLPVIRST AGGDSVQICT NPLDTFFPFD PCVLKRSKKF 540
IDPIYQVWED MSAEELQEFK KPMKKDIVED EDDDFLKGEV PQNDTVIGIT PSSFDTHFRS 600
PSSSVGSPPV LYMQPSPL 618 
Gene Ontology
 GO:0005730; C:nucleolus; IDA:HPA.
 GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
 GO:0008283; P:cell proliferation; IEA:Compara.
 GO:0007028; P:cytoplasm organization; IEA:Compara.
 GO:0048872; P:homeostasis of number of cells; IEA:Compara.
 GO:0001701; P:in utero embryonic development; IEA:Compara.
 GO:0043066; P:negative regulation of apoptotic process; IEA:Compara.
 GO:0007000; P:nucleolus organization; IEA:Compara.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; IEA:Compara.
 GO:2000142; P:regulation of DNA-dependent transcription, initiation; IEA:Compara.
 GO:0042254; P:ribosome biogenesis; IEA:Compara.
 GO:0006361; P:transcription initiation from RNA polymerase I promoter; IEA:Compara. 
Interpro
 IPR007991; RNA_pol_I_trans_ini_fac_RRN3. 
Pfam
 PF05327; RRN3 
SMART
  
PROSITE
  
PRINTS