CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-028350
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein kinase, cAMP-dependent, catalytic, alpha 
Protein Synonyms/Alias
 cAMP-dependent protein kinase catalytic subunit alpha 
Gene Name
 Prkaca 
Gene Synonyms/Alias
 rCG_51506 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
9GNAAAAKKGSEQESVubiquitination[1]
24KEFLAKAKEDFLKKWacetylation[2]
62FGRVMLVKHKESGNHacetylation[2]
79MKILDKQKVVKLKQIacetylation[2]
82LDKQKVVKLKQIEHTacetylation[2]
267SHFSSDLKDLLRNLLacetylation[2]
280LLQVDLTKRFGNLKNacetylation[2]
318VEAPFIPKFKGPGDTacetylation[2]
Reference
 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113]
 [2] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 351 AA 
Protein Sequence
MGNAAAAKKG SEQESVKEFL AKAKEDFLKK WETPSQNTAQ LDHFDRIKTL GTGSFGRVML 60
VKHKESGNHY AMKILDKQKV VKLKQIEHTL NEKRILQAVN FPFLVKLEFS FKDNSNLYMV 120
MEYVPGGEMF SHLRRIGRFS EPHARFYAAQ IVLTFEYLHS LDLIYRDLKP ENLLIDQQGY 180
IQVTDFGFAK RVKGRTWTLC GTPEYLAPEI ILSKGYNKAV DWWALGVLIY EMAAGYPPFF 240
ADQPIQIYEK IVSGKVRFPS HFSSDLKDLL RNLLQVDLTK RFGNLKNGVN DIKNHKWFAT 300
TDWIAIYQRK VEAPFIPKFK GPGDTSNFDD YEEEEIRVSI NEKCGKEFTE F 351 
Gene Ontology
 GO:0005813; C:centrosome; IEA:Compara.
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0031594; C:neuromuscular junction; IEA:Compara.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004691; F:cAMP-dependent protein kinase activity; IEA:Compara.
 GO:0071333; P:cellular response to glucose stimulus; IEA:Compara.
 GO:0071374; P:cellular response to parathyroid hormone stimulus; IEA:Compara.
 GO:0001707; P:mesoderm formation; IEA:Compara.
 GO:0018105; P:peptidyl-serine phosphorylation; IEA:Compara.
 GO:0071158; P:positive regulation of cell cycle arrest; IEA:Compara.
 GO:0046827; P:positive regulation of protein export from nucleus; IEA:Compara.
 GO:0046777; P:protein autophosphorylation; IEA:Compara.
 GO:0045667; P:regulation of osteoblast differentiation; IEA:Compara.
 GO:0061136; P:regulation of proteasomal protein catabolic process; IEA:Compara.
 GO:0050804; P:regulation of synaptic transmission; IEA:Compara.
 GO:2000810; P:regulation of tight junction assembly; IEA:Compara.
 GO:0048240; P:sperm capacitation; IEA:Compara. 
Interpro
 IPR000961; AGC-kinase_C.
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR002290; Ser/Thr_dual-sp_kinase_dom.
 IPR008271; Ser/Thr_kinase_AS. 
Pfam
 PF00069; Pkinase 
SMART
 SM00133; S_TK_X
 SM00220; S_TKc 
PROSITE
 PS51285; AGC_KINASE_CTER
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 
PRINTS