| Tag | Content |
|---|
| CPLM ID | CPLM-012883 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Myosin light chain kinase 3 |
Protein Synonyms/Alias | Cardiac-MyBP-C-associated Ca/CaM kinase; Cardiac-MLCK |
Gene Name | MYLK3 |
Gene Synonyms/Alias | MLCK |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 766 | MSATQCLKHEWLNNL | ubiquitination | [1] | | 776 | WLNNLPAKASRSKTR | ubiquitination | [1] | | 792 | KSQLLLQKYIAQRKW | ubiquitination | [1] |
|
Reference | [1] Global identification of modular cullin-RING ligase substrates. Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ. Cell. 2011 Oct 14;147(2):459-74. [ PMID: 21963094] |
Functional Description | Kinase that phosphorylates MYL2 in vitro. Promotes sarcomere formation in cardiomyocytes and increases cardiomyocyte contractility (By similarity). |
Sequence Annotation | DOMAIN 515 770 Protein kinase.
NP_BIND 521 529 ATP (By similarity).
ACT_SITE 636 636 Proton acceptor (By similarity).
BINDING 544 544 ATP (By similarity). |
Keyword | Alternative splicing; ATP-binding; Complete proteome; Cytoplasm; Kinase; Magnesium; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 819 AA |
Protein Sequence | MSGTSKESLG HGGLPGLGKT CLTTMDTKLN MLNEKVDQLL HFQEDVTEKL QSMCRDMGHL 60
ERGLHRLEAS RAPGPGGADG VPHIDTQAGW PEVLELVRAM QQDAAQHGAR LEALFRMVAA 120
VDRAIALVGA TFQKSKVADF LMQGRVPWRR GSPGDSPEEN KERVEEEGGK PKHVLSTSGV 180
QSDAREPGEE SQKADVLEGT AERLPPIRAS GLGADPAQAV VSPGQGDGVP GPAQAFPGHL 240
PLPTKVEAKA PETPSENLRT GLELAPAPGR VNVVSPSLEV APGAGQGASS SRPDPEPLEE 300
GTRLTPGPGP QCPGPPGLPA QARATHSGGE TPPRISIHIQ EMDTPGEMLM TGRGSLGPTL 360
TTEAPAAAQP GKQGPPGTGR CLQAPGTEPG EQTPEGAREL SPLQESSSPG GVKAEEEQRA 420
GAEPGTRPSL ARSDDNDHEV GALGLQQGKS PGAGNPEPEQ DCAARAPVRA EAVRRMPPGA 480
EAGSVVLDDS PAPPAPFEHR VVSVKETSIS AGYEVCQHEV LGGGRFGQVH RCTEKSTGLP 540
LAAKIIKVKS AKDREDVKNE INIMNQLSHV NLIQLYDAFE SKHSCTLVME YVDGGELFDR 600
ITDEKYHLTE LDVVLFTRQI CEGVHYLHQH YILHLDLKPE NILCVNQTGH QIKIIDFGLA 660
RRYKPREKLK VNFGTPEFLA PEVVNYEFVS FPTDMWSVGV ITYMLLSGLS PFLGETDAET 720
MNFIVNCSWD FDADTFEGLS EEAKDFVSRL LVKEKSCRMS ATQCLKHEWL NNLPAKASRS 780
KTRLKSQLLL QKYIAQRKWK KHFYVVTAAN RLRKFPTSP 819 |
Gene Ontology | GO:0015629; C:actin cytoskeleton; IEA:Compara. GO:0005829; C:cytosol; ISS:BHF-UCL. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0004683; F:calmodulin-dependent protein kinase activity; ISS:BHF-UCL. GO:0004687; F:myosin light chain kinase activity; ISS:BHF-UCL. GO:0055003; P:cardiac myofibril assembly; ISS:BHF-UCL. GO:0071347; P:cellular response to interleukin-1; IMP:BHF-UCL. GO:0060298; P:positive regulation of sarcomere organization; ISS:BHF-UCL. GO:0002528; P:regulation of vascular permeability involved in acute inflammatory response; IMP:BHF-UCL. GO:0045214; P:sarcomere organization; ISS:BHF-UCL. GO:0048769; P:sarcomerogenesis; ISS:BHF-UCL. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |