| Tag | Content |
|---|
| CPLM ID | CPLM-002014 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Vitamin D-binding protein |
Protein Synonyms/Alias | DBP; VDB; Gc-globulin; Group-specific component |
Gene Name | GC |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 51 | SLVLYSRKFPSGTFE | glycation | [1] |
|
Reference | [1] Proteomic profiling of nonenzymatically glycated proteins in human plasma and erythrocyte membranes. Zhang Q, Tang N, Schepmoes AA, Phillips LS, Smith RD, Metz TO. J Proteome Res. 2008 May;7(5):2025-32. [ PMID: 18396901] |
Functional Description | Multifunctional protein found in plasma, ascitic fluid, cerebrospinal fluid, and urine and on the surface of many cell types. In plasma, it carries the vitamin D sterols and prevents polymerization of actin by binding its monomers. DBP associates with membrane-bound immunoglobulin on the surface of B-lymphocytes and with IgG Fc receptor on the membranes of T-lymphocytes. |
Sequence Annotation | DOMAIN 17 208 Albumin 1.
DOMAIN 209 394 Albumin 2.
DOMAIN 395 474 Albumin 3.
CARBOHYD 288 288 N-linked (GlcNAc...) (Potential).
DISULFID 29 75
DISULFID 74 83 By similarity.
DISULFID 96 112
DISULFID 111 122
DISULFID 145 190
DISULFID 189 198
DISULFID 220 266
DISULFID 265 273
DISULFID 286 300
DISULFID 299 311
DISULFID 335 376
DISULFID 375 384
DISULFID 407 453
DISULFID 452 462 |
Keyword | 3D-structure; Actin-binding; Alternative splicing; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Polymorphism; Reference proteome; Repeat; Secreted; Signal; Transport; Vitamin D. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 474 AA |
Protein Sequence | MKRVLVLLLA VAFGHALERG RDYEKNKVCK EFSHLGKEDF TSLSLVLYSR KFPSGTFEQV 60
SQLVKEVVSL TEACCAEGAD PDCYDTRTSA LSAKSCESNS PFPVHPGTAE CCTKEGLERK 120
LCMAALKHQP QEFPTYVEPT NDEICEAFRK DPKEYANQFM WEYSTNYGQA PLSLLVSYTK 180
SYLSMVGSCC TSASPTVCFL KERLQLKHLS LLTTLSNRVC SQYAAYGEKK SRLSNLIKLA 240
QKVPTADLED VLPLAEDITN ILSKCCESAS EDCMAKELPE HTVKLCDNLS TKNSKFEDCC 300
QEKTAMDVFV CTYFMPAAQL PELPDVELPT NKDVCDPGNT KVMDKYTFEL SRRTHLPEVF 360
LSKVLEPTLK SLGECCDVED STTCFNAKGP LLKKELSSFI DKGQELCADY SENTFTEYKK 420
KLAERLKAKL PDATPKELAK LVNKRSDFAS NCCSINSPPL YCDSEIDAEL KNIL 474 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |