CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-009229
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Imidazole glycerol phosphate synthase subunit HisF 
Protein Synonyms/Alias
 IGP synthase cyclase subunit; IGP synthase subunit HisF; ImGP synthase subunit HisF; IGPS subunit HisF 
Gene Name
 hisF 
Gene Synonyms/Alias
 b2025; JW2007 
Created Date
 July 27, 2013 
Organism
 Escherichia coli (strain K12) 
NCBI Taxa ID
 83333 
Lysine Modification
Position
Peptide
Type
References
19VRDGQVVKGVQFRNHacetylation[1]
37GDIVPLAKRYAEEGAacetylation[1]
63SDGRVVDKSWVSRVAacetylation[1]
84FCVAGGIKSLEDAAKacetylation[1]
91KSLEDAAKILSFGADacetylation[1]
168DWVQEVQKRGAGEIVacetylation[1]
194GYDLEQLKKVREVCHacetylation[1]
236LAASVFHKQIINIGEacetylation[1]
Reference
 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 
Functional Description
 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. 
Sequence Annotation
 ACT_SITE 11 11 Potential.
 ACT_SITE 130 130 Potential.  
Keyword
 Amino-acid biosynthesis; Complete proteome; Cytoplasm; Direct protein sequencing; Histidine biosynthesis; Lyase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 258 AA 
Protein Sequence
MLAKRIIPCL DVRDGQVVKG VQFRNHEIIG DIVPLAKRYA EEGADELVFY DITASSDGRV 60
VDKSWVSRVA EVIDIPFCVA GGIKSLEDAA KILSFGADKI SINSPALADP TLITRLADRF 120
GVQCIVVGID TWYDAETGKY HVNQYTGDES RTRVTQWETL DWVQEVQKRG AGEIVLNMMN 180
QDGVRNGYDL EQLKKVREVC HVPLIASGGA GTMEHFLEAF RDADVDGALA ASVFHKQIIN 240
IGELKAYLAT QGVEIRIC 258 
Gene Ontology
 GO:0009382; C:imidazoleglycerol-phosphate synthase complex; IDA:EcoCyc.
 GO:0000107; F:imidazoleglycerol-phosphate synthase activity; IDA:EcoCyc.
 GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
 GO:0000105; P:histidine biosynthetic process; IDA:EcoCyc. 
Interpro
 IPR013785; Aldolase_TIM.
 IPR006062; His_biosynth.
 IPR004651; HisF.
 IPR011060; RibuloseP-bd_barrel. 
Pfam
 PF00977; His_biosynth 
SMART
  
PROSITE
  
PRINTS