CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018950
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 F-box-like/WD repeat-containing protein ebi 
Protein Synonyms/Alias
  
Gene Name
 ebi 
Gene Synonyms/Alias
 CG4063 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
102IVKTEPGKPGAVDSSacetylation[1]
Reference
 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 
Functional Description
 F-box-like component of E3 ubiquitin ligase complexes; involved in R7 photoreceptor cell differentiation, cone cell development and neuronal cell cycle control. E3 ubiquitin ligase complexes mediate ubiquitination and subsequent proteasomal degradation of target proteins. Required for specification of R7 photoreceptor cell fate in the eye by participating in the ubiquitination and subsequent proteasomal degradation of Tramtrack (ttk), a general inhibitor of photoreceptor differentiation. Required to block the S phase entry in the peripheral nervous system and central nervous system in a process that does not involve the degradation of ttk. Involved in cone cell development by preventing the transcriptional repression mediated by Su(H) on Dl, probably by participating in a E3 complex that contains sno and mediates the ubiquitination and subsequent proteasomal degradation of some component of the Su(H) repressor complex. 
Sequence Annotation
 DOMAIN 4 36 LisH.
 DOMAIN 41 84 F-box-like.
 REPEAT 353 392 WD 1.
 REPEAT 408 447 WD 2.
 REPEAT 449 488 WD 3.
 REPEAT 491 531 WD 4.
 REPEAT 532 571 WD 5.
 REPEAT 574 622 WD 6.
 REPEAT 625 664 WD 7.
 REPEAT 666 700 WD 8.  
Keyword
 Cell cycle; Complete proteome; Nucleus; Reference proteome; Repeat; Sensory transduction; Ubl conjugation pathway; Vision; WD repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 700 AA 
Protein Sequence
MSFSSDEVNF LVYRYLQESG FLHSAYVFGI ESHISQSNIN GALVPPAALL TILQKGLLYT 60
EVEWSVGEDG EVARPIEGLS LIDAVMPEVK PLKPIVKTEP GKPGAVDSSA PAGGNQNNNA 120
KPEIKIEPGT GVAGSAGGNK IAGSTTGTST PTDQSASEVD SSGNAANNAG GTYAGNNGAG 180
GNQASTGGSN STSTPAGGDL AAPGASQKKS QNSNEAGSSS SGNAGNANAT STDDAASSTS 240
TNGNSSTSSS VEQPTSGLTP AGGTVSTSNP DAAASGGAST ATGSKAPSGA VTIRVGAQGN 300
NVQSGSSNAQ SSAPSGTISS STSGGAGTPA ALVPMDIDEN IEIPESKARV LRGHESEVFI 360
CAWNPSRDLL ASGSGDSTAR IWDMSDANTN SNQLVLRHCI QKGGAEVPSN KDVTSLDWNC 420
DGSLLATGSY DGYARIWKTD GRLASTLGQH KGPIFALKWN KCGNYILSAG VDKTTIIWDA 480
STGQCTQQFA FHSAPALDVD WQTNQAFASC STDQRIHVCR LGVNEPIKTF KGHTNEVNAI 540
KWCPQGQLLA SCSDDMTLKI WSMNRDRCCH DLQAHSKEIY TIKWSPTGPG TNNPNTNLIL 600
ASASFDSTVR LWDVERGSCI HTLTKHTEPV YSVAFSPDGK HLASGSFDKC VHIWSTQTGQ 660
LVHSYKGTGG IFEVCWNSKG TKVGASASDG SVFVLDLRKF 700 
Gene Ontology
 GO:0005700; C:polytene chromosome; IDA:FlyBase.
 GO:0017053; C:transcriptional repressor complex; IGI:FlyBase.
 GO:0003682; F:chromatin binding; IDA:FlyBase.
 GO:0005525; F:GTP binding; ISS:FlyBase.
 GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
 GO:0022416; P:chaeta development; IMP:FlyBase.
 GO:0042676; P:compound eye cone cell fate commitment; TAS:FlyBase.
 GO:0007173; P:epidermal growth factor receptor signaling pathway; TAS:FlyBase.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IPI:GOC.
 GO:0007219; P:Notch signaling pathway; TAS:FlyBase.
 GO:0042461; P:photoreceptor cell development; IMP:FlyBase.
 GO:0031065; P:positive regulation of histone deacetylation; IDA:FlyBase.
 GO:0045572; P:positive regulation of imaginal disc growth; IMP:FlyBase.
 GO:0045747; P:positive regulation of Notch signaling pathway; IDA:FlyBase.
 GO:0042058; P:regulation of epidermal growth factor receptor signaling pathway; IMP:UniProtKB.
 GO:0030162; P:regulation of proteolysis; TAS:FlyBase.
 GO:0007601; P:visual perception; IEA:UniProtKB-KW.
 GO:0035220; P:wing disc development; IMP:FlyBase. 
Interpro
 IPR020472; G-protein_beta_WD-40_rep.
 IPR006594; LisH_dimerisation.
 IPR013720; LisH_dimerisation_subgr.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR019775; WD40_repeat_CS.
 IPR017986; WD40_repeat_dom. 
Pfam
 PF08513; LisH
 PF00400; WD40 
SMART
 SM00667; LisH
 SM00320; WD40 
PROSITE
 PS50896; LISH
 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 
PRINTS
 PR00320; GPROTEINBRPT.