UniProt Accession

 LAT3_HUMAN; O75387 

Genbank Protein ID

 AF045584; AB103033; BC001639 

Genbank Nucleotide ID

 AAC33004.1; BAD00152.1; AAH01639.1 

Protein Name

 Large neutral amino acids transporter small subunit 3 

Protein Synonyms/Alias

 L-type amino acid transporter 3; Prostate cancer overexpressed gene 1 protein; Solute carrier family 43 member 1 

Gene Name

 SLC43A1 

Gene Synonyms/Alias

 LAT3; PB39; POV1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
264	MGQRLSQKAPSLEDG	ubiquitination	[1, 2, 3]
382	YIMDWRIKDCVDAPT	ubiquitination	[2]
404	ARDGVATKSIRPRYC	ubiquitination	[2]

Reference

 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Sodium-independent, high affinity transport of large neutral amino acids. Has narrower substrate selectivity compared to SLC7A5 and SLC7A8 and mainly transports branched-chain amino acids and phenylalanine. Plays a role in the development of human prostate cancer, from prostatic intraepithelial neoplasia to invasive prostate cancer. 

Sequence Annotation

 CARBOHYD 57 57 N-linked (GlcNAc...) (Potential).
 CARBOHYD 212 212 N-linked (GlcNAc...) (Potential).
 CARBOHYD 229 229 N-linked (GlcNAc...) (Potential).  

Keyword

 Alternative splicing; Amino-acid transport; Complete proteome; Glycoprotein; Membrane; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 559 AA 

Protein Sequence

Gene Ontology

 GO:0005887; C:integral to plasma membrane; TAS:UniProtKB.
 GO:0015179; F:L-amino acid transmembrane transporter activity; IEA:Compara.
 GO:0015175; F:neutral amino acid transmembrane transporter activity; IDA:UniProtKB. 

Interpro

 IPR027199; LAT3.
 IPR011701; MFS.
 IPR016196; MFS_dom_general_subst_transpt.
 IPR027192; SLC43. 

Pfam

 PF07690; MFS_1 

SMART

  

PROSITE

  

PRINTS