UniProt Accession

 CP4CA_MOUSE; Q91WL5; A2A973; Q3UNE4; Q6P931; Q8N7N3 

Genbank Protein ID

 AK144260; AL627227; AL627182; AL627182; AL627227; CH466552; BC014721; BC025936; BC026582; BC031141; BC033924 

Genbank Nucleotide ID

 BAE25803.1; CAM18400.1; CAM18400.1; CAM21083.1; CAM21083.1; EDL30651.1; AAH14721.1; AAH25936.1; AAH26582.1; AAH31141.1; AAH33924.1 

Protein Name

 Cytochrome P450 4A12A 

Protein Synonyms/Alias

 CYPIVA12 

Gene Name

 Cyp4a12a 

Gene Synonyms/Alias

 Cyp4a12 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
66	LFGHKILKDQDLQDI	ubiquitination	[1]
78	QDILTRIKNFPSACP	ubiquitination	[1]
92	PQWLWGSKVRIQVYD	ubiquitination	[1]
104	VYDPDYMKLILGRSD	ubiquitination	[1]
154	AFHYDILKPYTEIMA	ubiquitination	[1]
213	VQLDRKYKSYIQAVE	ubiquitination	[1]
249	RVSSNGCKANSACKL	ubiquitination	[1]
255	CKANSACKLAHDHTD	ubiquitination	[1]
266	DHTDQVIKSRRIQLQ	ubiquitination	[1]
280	QDEEELEKLKKKRRL	ubiquitination	[1]
307	NGKSLSDKDLRAEVD	ubiquitination	[1]
347	EHQQRCRKEIQSLLG	ubiquitination	[1]
375	PYTTMCIKEALRIYP	ubiquitination	[1]
458	GARNCIGKQFAMNEL	acetylation	[2]
458	GARNCIGKQFAMNEL	ubiquitination	[1]
497	PRIVLKSKNGIHLHL	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123] 

Functional Description

 Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. 

Sequence Annotation

 METAL 455 455 Iron (heme axial ligand) (By similarity).
 BINDING 319 319 Heme (covalent; via 1 link) (By  

Keyword

 Complete proteome; Endoplasmic reticulum; Heme; Iron; Membrane; Metal-binding; Microsome; Monooxygenase; Oxidoreductase; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 508 AA 

Protein Sequence

Gene Ontology

 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0018685; F:alkane 1-monooxygenase activity; IDA:MGI.
 GO:0070330; F:aromatase activity; IEA:EC.
 GO:0009055; F:electron carrier activity; IEA:InterPro.
 GO:0020037; F:heme binding; IEA:InterPro.
 GO:0005506; F:iron ion binding; IEA:InterPro.
 GO:0006631; P:fatty acid metabolic process; ISS:UniProtKB. 

Interpro

 IPR001128; Cyt_P450.
 IPR017972; Cyt_P450_CS.
 IPR002401; Cyt_P450_E_grp-I. 

Pfam

 PF00067; p450 

SMART

  

PROSITE

 PS00086; CYTOCHROME_P450 

PRINTS

 PR00463; EP450I.
 PR00385; P450.