CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-003144
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 3-oxoacyl-[acyl-carrier-protein] synthase 1 
Protein Synonyms/Alias
 3-oxoacyl-[acyl-carrier-protein] synthase I; Beta-ketoacyl-ACP synthase I; KAS I 
Gene Name
 fabB 
Gene Synonyms/Alias
 fabC; b2323; JW2320 
Created Date
 July 27, 2013 
Organism
 Escherichia coli (strain K12) 
NCBI Taxa ID
 83333 
Lysine Modification
Position
Peptide
Type
References
40ITFSQELKDSGMRSHacetylation[1]
53SHVWGNVKLDTTGLIacetylation[1]
127MRGPRGLKAVGPYVVacetylation[1, 2]
136VGPYVVTKAMASGVSacetylation[1]
217KYNDTPEKASRTYDAacetylation[1]
282EGAVRCMKMAMHGVDacetylation[1]
308STPVGDVKELAAIREacetylation[1]
320IREVFGDKSPAISATacetylation[1, 2]
Reference
 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618]
 [2] Comprehensive profiling of protein lysine acetylation in Escherichia coli.
 Zhang K, Zheng S, Yang JS, Chen Y, Cheng Z.
 J Proteome Res. 2013 Feb 1;12(2):844-51. [PMID: 23294111] 
Functional Description
 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Specific for elongation from C-10 to unsaturated C-16 and C-18 fatty acids. 
Sequence Annotation
 ACT_SITE 163 163  
Keyword
 3D-structure; Acyltransferase; Complete proteome; Cytoplasm; Direct protein sequencing; Fatty acid biosynthesis; Fatty acid metabolism; Lipid biosynthesis; Lipid metabolism; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 406 AA 
Protein Sequence
MKRAVITGLG IVSSIGNNQQ EVLASLREGR SGITFSQELK DSGMRSHVWG NVKLDTTGLI 60
DRKVVRFMSD ASIYAFLSME QAIADAGLSP EAYQNNPRVG LIAGSGGGSP RFQVFGADAM 120
RGPRGLKAVG PYVVTKAMAS GVSACLATPF KIHGVNYSIS SACATSAHCI GNAVEQIQLG 180
KQDIVFAGGG EELCWEMACE FDAMGALSTK YNDTPEKASR TYDAHRDGFV IAGGGGMVVV 240
EELEHALARG AHIYAEIVGY GATSDGADMV APSGEGAVRC MKMAMHGVDT PIDYLNSHGT 300
STPVGDVKEL AAIREVFGDK SPAISATKAM TGHSLGAAGV QEAIYSLLML EHGFIAPSIN 360
IEELDEQAAG LNIVTETTDR ELTTVMSNSF GFGGTNATLV MRKLKD 406 
Gene Ontology
 GO:0005829; C:cytosol; IDA:UniProtKB.
 GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:EC.
 GO:0006633; P:fatty acid biosynthetic process; IGI:EcoliWiki. 
Interpro
 IPR018201; Ketoacyl_synth_AS.
 IPR014031; Ketoacyl_synth_C.
 IPR014030; Ketoacyl_synth_N.
 IPR016039; Thiolase-like.
 IPR016038; Thiolase-like_subgr. 
Pfam
 PF00109; ketoacyl-synt
 PF02801; Ketoacyl-synt_C 
SMART
  
PROSITE
 PS00606; B_KETOACYL_SYNTHASE 
PRINTS