CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-001330
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Eukaryotic translation initiation factor 3 subunit E 
Protein Synonyms/Alias
 eIF3e; Eukaryotic translation initiation factor 3 subunit 6 
Gene Name
 eIF3-S6 
Gene Synonyms/Alias
 Int6; CG9677 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
269RTRRNALKDLIKVIQacetylation[1]
Reference
 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 
Functional Description
 Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome (By similarity). 
Sequence Annotation
 DOMAIN 284 389 PCI.  
Keyword
 Complete proteome; Cytoplasm; Initiation factor; Protein biosynthesis; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 435 AA 
Protein Sequence
MANFDLTRIN CQFLDRHLTF PLLEFLCGKE IYNQQELLEY ILETVNKTNM IDYTMDTRKR 60
LNLSQEMPEE LVQRKAEVLA TLKQLQNEVA PIMKATDILK NGESMKDSKT FVNALQKDYN 120
FKVEHLESAY KLAKYLYECG NYQESTSYLY FCLIVMSPND KNYLNVLWGK LAAEILTLNW 180
NTALEDLTRL RDYIDNANFS TIQALQQRTW LIHWSVLVFF NHPKGRDLII EMFLYKPLYL 240
NAIQTMCPHI MRYLATAVVI NRTRRNALKD LIKVIQQESY TYRDPITEFL ECLYVNFDFE 300
GARLKLHECQ TVILNDFFIV ACLNEFVEDA RLMIFETFCR IHQCITISML ADKLNMKPNE 360
AECWIVNLIR NARLNAKIDS KLGHVVMGTQ PLSPYQQLVE KIDSLSMRSE HLAGLIERKS 420
KQKQNQESAD SWKYY 435 
Gene Ontology
 GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:HAMAP.
 GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:HAMAP.
 GO:0005852; C:eukaryotic translation initiation factor 3 complex; ISS:FlyBase.
 GO:0043231; C:intracellular membrane-bounded organelle; IDA:FlyBase.
 GO:0003743; F:translation initiation factor activity; ISS:FlyBase.
 GO:0001731; P:formation of translation preinitiation complex; IEA:HAMAP.
 GO:0048812; P:neuron projection morphogenesis; IMP:FlyBase.
 GO:0006911; P:phagocytosis, engulfment; IMP:FlyBase.
 GO:0051726; P:regulation of cell cycle; IDA:FlyBase.
 GO:0006446; P:regulation of translational initiation; IEA:HAMAP. 
Interpro
 IPR016650; eIF3e.
 IPR019010; eIF3e_N.
 IPR000717; PCI_dom.
 IPR011991; WHTH_DNA-bd_dom. 
Pfam
 PF09440; eIF3_N
 PF01399; PCI 
SMART
 SM00088; PINT 
PROSITE
  
PRINTS