UniProt Accession

 DDTL_HUMAN; A6NHG4; B4DJJ7 

Genbank Protein ID

 AK296110; DC339950; AP000350 

Genbank Nucleotide ID

 BAG58859.1 

Protein Name

 D-dopachrome decarboxylase-like protein 

Protein Synonyms/Alias

 D-dopachrome tautomerase-like protein 

Gene Name

 DDTL 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
21	RVPAGLEKRLCAAAA	acetylation	[1]
21	RVPAGLEKRLCAAAA	ubiquitination	[1, 2, 3]
33	AAASILGKPADRVNV	ubiquitination	[1]

Reference

 [1] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 May have lyase activity (Potential). 

Sequence Annotation

  

Keyword

 Complete proteome; Cytoplasm; Lyase; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 134 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0016829; F:lyase activity; IEA:UniProtKB-KW. 

Interpro

 IPR001398; Macrophage_inhib_fac.
 IPR019829; Macrophage_inhib_fac_CS.
 IPR014347; Tautomerase/MIF_sf. 

Pfam

 PF01187; MIF 

SMART

  

PROSITE

 PS01158; MIF 

PRINTS