UniProt Accession

 SNX6_MOUSE; Q6P8X1; Q9CZ03 

Genbank Protein ID

 AK013158; BC061028 

Genbank Nucleotide ID

 BAB28684.1; AAH61028.1 

Protein Name

 Sorting nexin-6 

Protein Synonyms/Alias

 Sorting nexin-6, N-terminally processed 

Gene Name

 Snx6 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
60	KSSLPNFKQNEFSVV	ubiquitination	[1]
119	EGEGSMTKEEFTKMK	ubiquitination	[1]
269	DICKFFLKVSELFDK	ubiquitination	[1]
276	KVSELFDKTRKIEAR	ubiquitination	[1]
297	LKLSDLLKYYLRESQ	ubiquitination	[1]
307	LRESQAAKDLLYRRS	ubiquitination	[1]
325	VDYENANKALDKARA	ubiquitination	[1]
350	SQQLCCQKFEKISES	acetylation	[2]
366	KQELIDFKTRRVAAF	ubiquitination	[1]
386	ELAELELKHAKGNLQ	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 

Functional Description

 May be involved in several stages of intracellular trafficking. Plays a role in retrograde protein transport from endosomes to the trans-Golgi network. May function as link between transport vesicles and dynactin. Negatively regulates retrograde transport of BACE1 from the cell surface to the trans-Golgi network. May contribute to transcription regulation (By similarity). Promotes lysosomal degradation of CDKN1B. 

Sequence Annotation

 DOMAIN 26 173 PX.
 REGION 41 47 Phosphatidylinositol bisphosphate binding
 REGION 100 106 Phosphatidylinositol bisphosphate binding
 REGION 114 117 Phosphatidylinositol bisphosphate binding
 MOD_RES 1 1 N-acetylmethionine (By similarity).
 MOD_RES 2 2 N-acetylmethionine; in Sorting nexin-6,  

Keyword

 Acetylation; Complete proteome; Cytoplasm; Cytoplasmic vesicle; Direct protein sequencing; Endosome; Lipid-binding; Membrane; Nucleus; Protein transport; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 406 AA 

Protein Sequence

Gene Ontology

 GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
 GO:0031901; C:early endosome membrane; ISS:UniProtKB.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
 GO:0007154; P:cell communication; IEA:InterPro.
 GO:0006886; P:intracellular protein transport; ISS:UniProtKB.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; IEA:Compara.
 GO:0030512; P:negative regulation of transforming growth factor beta receptor signaling pathway; IEA:Compara.
 GO:0042147; P:retrograde transport, endosome to Golgi; ISS:UniProtKB. 

Interpro

 IPR027267; AH/BAR-dom.
 IPR001683; Phox.
 IPR014637; Snx5_Snx6.
 IPR015404; Vps5_C. 

Pfam

 PF00787; PX
 PF09325; Vps5 

SMART

  

PROSITE

 PS50195; PX 

PRINTS